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PKM2-driven glycolysis mediates rotenone neurotoxicity via MG-Hs in Parkinson's disease.

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Title: PKM2-driven glycolysis mediates rotenone neurotoxicity via MG-Hs in Parkinson's disease.
Authors: Li R; Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China., Ma JW; Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China., Chen H; Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China., Mu D; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China., Qu L; School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan, China., Wang D; Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. wangdan22@nsmc.edu.cn., Zhao Y; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China. zhaoya@nsmc.edu.cn.
Source: Scientific reports [Sci Rep] 2026 May 30. Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PKM2-driven glycolysis mediates rotenone neurotoxicity via MG-Hs in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China.<br /><searchLink fieldCode="AU" term="%22Ma+JW%22">Ma JW</searchLink>; Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China.<br /><searchLink fieldCode="AU" term="%22Mu+D%22">Mu D</searchLink>; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China.<br /><searchLink fieldCode="AU" term="%22Qu+L%22">Qu L</searchLink>; School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. wangdan22@nsmc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, China. zhaoya@nsmc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 May 30. <i>Date of Electronic Publication: </i>2026 May 30.
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        Value: 10.1038/s41598-026-54865-7
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      – TitleFull: PKM2-driven glycolysis mediates rotenone neurotoxicity via MG-Hs in Parkinson's disease.
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              Text: 2026 May 30
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