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MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.

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Title: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.
Authors: Wermke M; NCT/UCC Early Clinical Trial Unit and Department of Medicine I, Dresden University of Technology, Dresden, Germany., Ochsenreither S; Charité Universitätsmedizin Berlin, Berlin, Germany., Jaeger D; National Center for Tumor Diseases, Heidelberg, Germany., Becker H; Department of Hematology, Oncology, and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany., Bleckmann A; Department of Medicine A for Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany., Bozorgmehr F; National Center for Tumor Diseases, Heidelberg, Germany.; Thoraxklinik Heidelberg gGmbH, University Hospital Heidelberg, Heidelberg, Germany., Chatterjee M; University Hospital Würzburg, Comprehensive Cancer Center Mainfranken, Würzburg, Germany., Groepper S; Marien Hospital Düsseldorf, Düsseldorf, Germany., Haenel M; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany., Hecker JS; Department of Medicine III, Technical University of Munich (TUM), Klinikum rechts der Isar, School of Medicine and Health, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich (TUM), Munich, Germany., Häring MF; University Hospital of Tübingen, Tübingen, Germany., Heudobler D; University Hospital Regensburg, Regensburg, Germany., Hilf N; Immatics Biotechnologies GmbH, Tübingen, Germany., Hofmann M; Immatics Biotechnologies GmbH, Tübingen, Germany., Hutt M; Immatics Biotechnologies GmbH, Tübingen, Germany., Mayer-Mokler A; Immatics Biotechnologies GmbH, Tübingen, Germany., Missel S; Immatics Biotechnologies GmbH, Tübingen, Germany., Ruh M; Immatics Biotechnologies GmbH, Tübingen, Germany., Schuster H; Immatics Biotechnologies GmbH, Tübingen, Germany., Veremchuk O; Immatics Biotechnologies GmbH, Tübingen, Germany., Kleemiss M; University Hospital Bonn, Bonn, Germany., Knop S; Nuremberg General Hospital, Nuremberg, Germany., Laban S; Department of Otorhinolaryngology and Head & Neck Surgery, Ulm University Medical Center, Ulm, Germany., Sebastian M; University Hospital, Goethe University Frankfurt, Frankfurt Cancer Institute, Frankfurt, Germany., Spoerl S; University Hospital Erlangen, Erlangen, Germany., Britten CM; Immatics Biotechnologies GmbH, Tübingen, Germany., Reinhardt C; Immatics Biotechnologies GmbH, Tübingen, Germany. Carsten.Reinhardt@immatics.com.
Source: Nature medicine [Nat Med] 2026 May 31. Date of Electronic Publication: 2026 May 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.
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  Data: <searchLink fieldCode="AU" term="%22Wermke+M%22">Wermke M</searchLink>; NCT/UCC Early Clinical Trial Unit and Department of Medicine I, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ochsenreither+S%22">Ochsenreither S</searchLink>; Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jaeger+D%22">Jaeger D</searchLink>; National Center for Tumor Diseases, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+H%22">Becker H</searchLink>; Department of Hematology, Oncology, and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bleckmann+A%22">Bleckmann A</searchLink>; Department of Medicine A for Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Bozorgmehr+F%22">Bozorgmehr F</searchLink>; National Center for Tumor Diseases, Heidelberg, Germany.; Thoraxklinik Heidelberg gGmbH, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chatterjee+M%22">Chatterjee M</searchLink>; University Hospital Würzburg, Comprehensive Cancer Center Mainfranken, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Groepper+S%22">Groepper S</searchLink>; Marien Hospital Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Haenel+M%22">Haenel M</searchLink>; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Hecker+JS%22">Hecker JS</searchLink>; Department of Medicine III, Technical University of Munich (TUM), Klinikum rechts der Isar, School of Medicine and Health, Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Häring+MF%22">Häring MF</searchLink>; University Hospital of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Heudobler+D%22">Heudobler D</searchLink>; University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hilf+N%22">Hilf N</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+M%22">Hofmann M</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hutt+M%22">Hutt M</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mayer-Mokler+A%22">Mayer-Mokler A</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Missel+S%22">Missel S</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ruh+M%22">Ruh M</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schuster+H%22">Schuster H</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Veremchuk+O%22">Veremchuk O</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kleemiss+M%22">Kleemiss M</searchLink>; University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Knop+S%22">Knop S</searchLink>; Nuremberg General Hospital, Nuremberg, Germany.<br /><searchLink fieldCode="AU" term="%22Laban+S%22">Laban S</searchLink>; Department of Otorhinolaryngology and Head & Neck Surgery, Ulm University Medical Center, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Sebastian+M%22">Sebastian M</searchLink>; University Hospital, Goethe University Frankfurt, Frankfurt Cancer Institute, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Spoerl+S%22">Spoerl S</searchLink>; University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Britten+CM%22">Britten CM</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+C%22">Reinhardt C</searchLink>; Immatics Biotechnologies GmbH, Tübingen, Germany. Carsten.Reinhardt@immatics.com.
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