Gut microbiome functional pathways outperform taxonomic profiles in predicting immune checkpoint inhibitor response in non-small cell lung cancer: an interpretable machine learning approach with SHAP.
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| Title: | Gut microbiome functional pathways outperform taxonomic profiles in predicting immune checkpoint inhibitor response in non-small cell lung cancer: an interpretable machine learning approach with SHAP. |
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| Authors: | Wei F; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Yokohama, Japan., Nakahara Y; Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan.; Department of Respiratory Medicine, Kitasato University School of Medicine, Sagamihara, Japan., Isobe J; Department of Hospital Pharmaceutics, School of Pharmacy, Showa Medical University, Tokyo, Japan., Igarashi Y; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Saito H; Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan., Murakami S; Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan., Kondo T; Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan., Himuro H; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Yokohama, Japan., Kouro T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Yokohama, Japan., Matsui T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Yokohama, Japan.; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan., Wada S; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Tsunoda T; Division of Medical Oncology, Department of Medicine, School of Medicine, Showa Medical University, Tokyo, Japan., Yoshimura K; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Sasada T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Yokohama, Japan. |
| Source: | Frontiers in immunology [Front Immunol] 2026 May 15; Vol. 17, pp. 1832317. Date of Electronic Publication: 2026 May 15 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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