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N‑Benzyl-Tryptamine Derivatives as Serotonin 5‑HT2 Receptor Ligands: Synthesis and Structure-Affinity/Activity Relationships.

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Title: N‑Benzyl-Tryptamine Derivatives as Serotonin 5‑HT2 Receptor Ligands: Synthesis and Structure-Affinity/Activity Relationships.
Authors: Martínez-Afani D; Chemobiodynamics Laboratory, Department of Chemistry, Faculty of Sciences, University of Chile, Santiago 7800003, Chile.; Department of Organic Chemistry and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380492, Chile., Soares BA; Chemobiodynamics Laboratory, Department of Chemistry, Faculty of Sciences, University of Chile, Santiago 7800003, Chile.; Institute of Exact and Technological Sciences, Federal University of Jataí, Jataí, Goiás 75801615, Brazil., Mella-Raipán J; Institute of Chemistry and Biochemistry, Faculty of Sciences, University of Valparaíso, Valparaíso 2360102, Chile.; Centro de Investigación, Desarrollo E Innovación de Productos Bioactivos (CInBIO), University of Valparaíso, Valparaíso 2360102, Chile., Brea J; Biofarma Research Group, CiMUS, Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15705, Spain., Loza MI; Centro de Investigación, Desarrollo E Innovación de Productos Bioactivos (CInBIO), University of Valparaíso, Valparaíso 2360102, Chile., Pottie E; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent 9000, Belgium., Stove CP; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent 9000, Belgium., Cassels BK; Chemobiodynamics Laboratory, Department of Chemistry, Faculty of Sciences, University of Chile, Santiago 7800003, Chile.
Source: ACS omega [ACS Omega] 2026 May 13; Vol. 11 (20), pp. 29638-29653. Date of Electronic Publication: 2026 May 13 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
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  Data: N‑Benzyl-Tryptamine Derivatives as Serotonin 5‑HT<subscript>2</subscript> Receptor Ligands: Synthesis and Structure-Affinity/Activity Relationships.
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