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Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells.

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Title: Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells.
Authors: Kandhavelu J; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Subramanian K; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Moodley N; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Abass KS; College of Veterinary Medicine, Department of Physiology,‌‌ Biochemistry, and Pharmacology, University of Kirkuk, Kirkuk, Iraq., Sureka C; Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia., Kandhavelu M; Molecular Signaling Group, Faculty of Medicine and Health Technology, BioMediTech, ‌‌Tampere University and Tays Cancer Center, Tampere, Finland., Ruff P; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Penny C; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Source: PloS one [PLoS One] 2026 Jun 01; Vol. 21 (6), pp. e0348215. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Kandhavelu+J%22">Kandhavelu J</searchLink>; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Subramanian+K%22">Subramanian K</searchLink>; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Moodley+N%22">Moodley N</searchLink>; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Abass+KS%22">Abass KS</searchLink>; College of Veterinary Medicine, Department of Physiology,‌‌ Biochemistry, and Pharmacology, University of Kirkuk, Kirkuk, Iraq.<br /><searchLink fieldCode="AU" term="%22Sureka+C%22">Sureka C</searchLink>; Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Kandhavelu+M%22">Kandhavelu M</searchLink>; Molecular Signaling Group, Faculty of Medicine and Health Technology, BioMediTech, ‌‌Tampere University and Tays Cancer Center, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Ruff+P%22">Ruff P</searchLink>; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Penny+C%22">Penny C</searchLink>; Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
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