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Dynamic genetic and nongenetic RAS pathway activation drives resistance to FLT3 and BCL2 inhibitor therapy.

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Title: Dynamic genetic and nongenetic RAS pathway activation drives resistance to FLT3 and BCL2 inhibitor therapy.
Authors: Kennedy VE; Stanford University, Stanford, California, United States., Peretz CAC; University of California San Francisco, San Francisco, California, United States., Walia A; Brigham and Women's Hospital, Boston, Massachusetts, United States., Chyla B; Abbvie, North Chicago, Illinois, United States., Sun Y; AbbVie, Inc, North Chicago, Illinois, United States., Hill JE; Astellas Pharma, Northbrook, Illinois, United States., Tran E; University of California San Francisco, San Francisco, California, United States., Koh AD; University of California San Francisco, San Francisco, California, United States., Ferng TT; University of California (San Francisco), San Francisco, California, United States., Pintar S; University of California San Francisco, San Francisco, California, United States., Jones M; University of California San Francisco, Fremont, California, United States., Popescu B; University of California San Francisco, San Francisco, California, United States., Lomeli I; University of California San Francisco, San Francisco, California, United States., Chehab F; University of California, San Francisco., Murad N; University of California San Francisco, San Francisco, California, United States., John A; University of California San Francisco, San Francisco, California, United States., Roy RP; University of California San Francisco, San Francisco, California, United States., Olshen AB; UCSF, San Francisco, California, United States., Berryhill CA; Indiana University, Indianapolis, Indiana, United States., Davis C; Indiana University, Indianapolis, Indiana, United States., Angus SP; Indiana University School of Medicine, Indianapolis, Indiana, United States., Rivera JM; Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, United States., Meshulam A; University of California, San Francisco, San Francisco, California, United States., Stieglitz E; UCSF Benioff Children's Hospitals, San Francisco, California, United States., Joshi SK; Stanford Health Care, Palo Alto, California, United States., Traer E; Oregon Health & Science University, Portland, Oregon, United States., Dail M; Illuminate Biosciences, Moss Beach, California, United States., Hamidi H; Genentech, Inc, South San Francisco, California, United States., Altman JK; Northwestern University, Chicago, Illinois, United States., Daver NG; University of Texas, MD Anderson Cancer Center, Houston, Texas, United States., Levis MJ; Johns Hopkins University, Baltimore, Maryland, United States., McCloskey J; John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States., Perl AE; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Smith CC; University of California (San Francisco), San Francisco, California, United States.
Source: Blood [Blood] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kennedy+VE%22">Kennedy VE</searchLink>; Stanford University, Stanford, California, United States.<br /><searchLink fieldCode="AU" term="%22Peretz+CAC%22">Peretz CAC</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Walia+A%22">Walia A</searchLink>; Brigham and Women's Hospital, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Chyla+B%22">Chyla B</searchLink>; Abbvie, North Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; AbbVie, Inc, North Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Hill+JE%22">Hill JE</searchLink>; Astellas Pharma, Northbrook, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Tran+E%22">Tran E</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Koh+AD%22">Koh AD</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Ferng+TT%22">Ferng TT</searchLink>; University of California (San Francisco), San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Pintar+S%22">Pintar S</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Jones+M%22">Jones M</searchLink>; University of California San Francisco, Fremont, California, United States.<br /><searchLink fieldCode="AU" term="%22Popescu+B%22">Popescu B</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Lomeli+I%22">Lomeli I</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Chehab+F%22">Chehab F</searchLink>; University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Murad+N%22">Murad N</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22John+A%22">John A</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Roy+RP%22">Roy RP</searchLink>; University of California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Olshen+AB%22">Olshen AB</searchLink>; UCSF, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Berryhill+CA%22">Berryhill CA</searchLink>; Indiana University, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Davis+C%22">Davis C</searchLink>; Indiana University, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Angus+SP%22">Angus SP</searchLink>; Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Rivera+JM%22">Rivera JM</searchLink>; Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Meshulam+A%22">Meshulam A</searchLink>; University of California, San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Stieglitz+E%22">Stieglitz E</searchLink>; UCSF Benioff Children's Hospitals, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Joshi+SK%22">Joshi SK</searchLink>; Stanford Health Care, Palo Alto, California, United States.<br /><searchLink fieldCode="AU" term="%22Traer+E%22">Traer E</searchLink>; Oregon Health & Science University, Portland, Oregon, United States.<br /><searchLink fieldCode="AU" term="%22Dail+M%22">Dail M</searchLink>; Illuminate Biosciences, Moss Beach, California, United States.<br /><searchLink fieldCode="AU" term="%22Hamidi+H%22">Hamidi H</searchLink>; Genentech, Inc, South San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Altman+JK%22">Altman JK</searchLink>; Northwestern University, Chicago, Illinois, United States.<br /><searchLink fieldCode="AU" term="%22Daver+NG%22">Daver NG</searchLink>; University of Texas, MD Anderson Cancer Center, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Levis+MJ%22">Levis MJ</searchLink>; Johns Hopkins University, Baltimore, Maryland, United States.<br /><searchLink fieldCode="AU" term="%22McCloskey+J%22">McCloskey J</searchLink>; John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Perl+AE%22">Perl AE</searchLink>; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States.<br /><searchLink fieldCode="AU" term="%22Smith+CC%22">Smith CC</searchLink>; University of California (San Francisco), San Francisco, California, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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