Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects.
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| Title: | Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects. |
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| Authors: | Brito Nunes C; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia. c.britonunes@uq.edu.au., Rukins V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Cisse AH; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., White F; Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada., McBride N; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Kuang A; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Allard C; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Ronkainen J; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland., Hughes A; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Elliott A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Thorleifsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Vaudel M; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Bergen, Norway., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Gu Y; School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China., Lamri A; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton Health Sciences, Hamiton, ON, Canada., Chen L; Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tuhkanen J; Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lahti J; Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland., Calas L; Center for Research in Epidemiology and StatisticS (CRESS), INRAE, Inserm, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France., Muntaner M; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement, Lille, France., Karhunen V; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland., Choi J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea., Heiskala A; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland., Hatem G; Department of Clinical Sciences, Genetics and Diabetes, Lund University, Malmö, Sweden., Fragoso-Bargas N; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Rifas-Shiman SL; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA., Paz-Lopez G; Unidad de Bioinformática, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain., Stinson SE; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Section for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Bhowmik B; Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh., Ahlqvist E; Department of Clinical Sciences, Genetics and Diabetes, Lund University, Malmö, Sweden., Deleuze JF; Centre National de Recherche en Génomique Humaine (CNRGH), CEA, Université Paris-Saclay, Evry, France., Eriksson JG; Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Park J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea., Teo K; Population Health Research Institute, Hamilton Health Sciences, Hamiton, ON, Canada., Räikkönen K; Folkhälsan Research Centre, Helsinki, Finland., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Molina-Vega M; Unidad de Gestión Clínica Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.; Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y la Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain., Subbarao P; Department of Pediatrics, Hospital for Sick Children (SickKids), University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Beaumont RN; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Johansson S; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Engelbrechtsen L; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Gynaecology and Obstetrics, Herlev Hospital, University of Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, Faculty of Health, University of Copenhagen, Copenhagen, Denmark., Morcillo S; Unidad de Gestión Clínica Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.; Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y la Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain., Oken E; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA., Quigstad E; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway., Birkeland KI; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Vääräsmäki M; Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Welfare Epidemiology and Monitoring Unit, Department of Public Health, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland., Hattersley AT; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Sebert S; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland., Hitman GA; Centre for Genomics and Child Health, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Järvelin MR; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, London, UK., Prasad RB; Department of Clinical Sciences, Genetics and Diabetes, Lund University, Malmö, Sweden., Heude B; Center for Research in Epidemiology and StatisticS (CRESS), INRAE, Inserm, Université Paris Cité and Université Sorbonne Paris Nord, Paris, France., Meirhaeghe A; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement, Lille, France., Bouchard L; Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.; Clinical Department of Laboratory Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) du Saguenay-Lac-St-Jean, Saguenay, QC, Canada., Jacques PÉ; Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Laivuori H; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Tampere, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Tan KH; KK Women's and Children's Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Anand SS; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton Health Sciences, Hamiton, ON, Canada., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Liu S; School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China., Njølstad PR; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway., Steinthorsdottir V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Widén E; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Keikkala E; Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Welfare Epidemiology and Monitoring Unit, Department of Public Health, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland., Scholtens DM; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lowe WL; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Morris AP; Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Zöllner J; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK., Borges MC; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Hivert MF; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Departement de Medicine, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada., Freathy RM; Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK., Evans DM; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD, Australia., Moen GH; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia. g.moen@uq.edu.au.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. g.moen@uq.edu.au.; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, QLD, Australia. g.moen@uq.edu.au. |
| Corporate Authors: | Estonian Biobank Research Team, Genes & Health Research Team |
| Source: | Nature communications [Nat Commun] 2026 Jun 01; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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