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Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study Dataset.

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Title: Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study Dataset.
Authors: Cidade JP; Intensive Care Unit 4, Department of Intensive Care, São Francisco Xavier Hospital, ULSLO, Lisbon, Portugal.; Nova Medical School, Clinical Medicine, CHRC, NOVA University of Lisbon, Lisbon, Portugal., Póvoa P; Intensive Care Unit 4, Department of Intensive Care, São Francisco Xavier Hospital, ULSLO, Lisbon, Portugal.; Nova Medical School, Clinical Medicine, CHRC, NOVA University of Lisbon, Lisbon, Portugal.; Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, OUH Odense University Hospital, 5000, Odense C, Denmark., Depuydt P; Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium., Dhaese S; Division of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Bruges, Belgium., De Smet K; Department of Emergency Medicine, Leuven University Hospitals, Leuven, Belgium., Tabah A; Intensive Care Unit, Redcliffe Hospital, Redcliffe, QLD, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, Australia., Akova M; Department of Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey., Cotta MO; University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.; Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia., De Pascale G; Dipartimento di Scienza dell'Emergenza, Anestesiologiche e della Rianimazione - UOC di Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica - Istituto di Anestesia e Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Dimopoulos G; Department of Critical Care, EVGENIDIO Hospital, Athens, Greece.; Medical School, University of Athens, Athens, Greece., Fujitani S; Emergency Medicine and Critical Care Medicine, St. Marianna University Hospital, Kawasaki, Kanagawa, Japan., Garnacho-Montero J; Intensive Care Clinical Unit, Hospital Universitario Virgen del Rocío, Seville, Spain., Leone M; Aix-Marseille Universite, Assistance Publique Hopitaux de Marseille, Hopital Nord, Service d'Anesthesie et de Reanimation, Marseille, France., Lipman J; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; UR-UM 103, University of Montpellier, Division of Anesthesia, Critical Care, Emergency and Pain Medicine, Nîmes University Hospital, Nîmes, France.; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, and Queensland University of Technology, Brisbane, Australia., Ostermann M; Department of Critical Care, King's College London, Guy's and St Thomas' Hospital, London, UK., Paiva JA; Intensive Care Department, Unidade Local de Saude Sao Joao EPE, Porto, Portugal.; Faculdade de Medicina da Universidade do Porto, Porto, Portugal.; Grupo de Infeccao e Sepsis, Porto, Portugal., Schouten J; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Scientific Center for Quality of Healthcare, IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands., Sjövall F; Department of Intensive and Perioperative Care, Skane University Hospital, Malmo, Sweden.; Department of Clinical Sciences, Lund University, Malmö, Sweden., Timsit JF; Universite de Paris, Sorbonne Paris Cite, UMR 1137, IAME, Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat-Claude Bernard Hospital, 75018, Paris, France., Roberts JA; UR-UM 103, University of Montpellier, Division of Anesthesia, Critical Care, Emergency and Pain Medicine, Nîmes University Hospital, Nîmes, France.; Frazer Institute, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Australia.; Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, Australia.; Department of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia., Zahar JR; Prevention du Risque Infectieux et Maitrise de l'Antibiothérapie Unit, GH Paris Seine Saint Denis, APHP, Bobigny, France., Zand F; Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Zirpe K; Grant Medical Foundation, Ruby Hall Clinic, Pune, Maharashtra, India., De Waele JJ; Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., De Bus L; Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium. liesbet.debus@ugent.be.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. liesbet.debus@ugent.be.
Corporate Authors: DIANA Study Group
Source: Intensive care medicine [Intensive Care Med] 2026 Jun; Vol. 52 (6), pp. 1196-1209. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
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  Data: Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study Dataset.
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  Data: <searchLink fieldCode="AU" term="%22Cidade+JP%22">Cidade JP</searchLink>; Intensive Care Unit 4, Department of Intensive Care, São Francisco Xavier Hospital, ULSLO, Lisbon, Portugal.; Nova Medical School, Clinical Medicine, CHRC, NOVA University of Lisbon, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Póvoa+P%22">Póvoa P</searchLink>; Intensive Care Unit 4, Department of Intensive Care, São Francisco Xavier Hospital, ULSLO, Lisbon, Portugal.; Nova Medical School, Clinical Medicine, CHRC, NOVA University of Lisbon, Lisbon, Portugal.; Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, OUH Odense University Hospital, 5000, Odense C, Denmark.<br /><searchLink fieldCode="AU" term="%22Depuydt+P%22">Depuydt P</searchLink>; Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Dhaese+S%22">Dhaese S</searchLink>; Division of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Bruges, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Smet+K%22">De Smet K</searchLink>; Department of Emergency Medicine, Leuven University Hospitals, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Tabah+A%22">Tabah A</searchLink>; Intensive Care Unit, Redcliffe Hospital, Redcliffe, QLD, Australia.; Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Faculty of Health, Queensland University of Technology, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Akova+M%22">Akova M</searchLink>; Department of Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Cotta+MO%22">Cotta MO</searchLink>; University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.; Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22De+Pascale+G%22">De Pascale G</searchLink>; Dipartimento di Scienza dell'Emergenza, Anestesiologiche e della Rianimazione - UOC di Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica - Istituto di Anestesia e Rianimazione, Fondazione Policlinico Universitario A. 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