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The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosamines.

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Title: The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosamines.
Authors: Djuari MA; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany., Londenberg A; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany., Bassan A; Innovatune Srl, Padua, Italy., Cross K; INSTEM, Columbus, OH, USA., Elenschneider L; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany., Escher SE; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany., Fahrer J; Division of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Kaiserslautern, Germany., Fangmann J; LiverCenter Hannover (LCH), KRH Klinikum Region Hannover, Hannover, Germany., Felske C; Division of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Kaiserslautern, Germany., Frötschl R; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany., Haas B; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany., Johnson GE; Swansea University Medical School, Wales, UK., Vogel M; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany., Whomsley R; European Medicines Agency, Amsterdam, Netherlands., Ziemann C; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany. christina.ziemann@item.fraunhofer.de.
Source: Archives of toxicology [Arch Toxicol] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Djuari+MA%22">Djuari MA</searchLink>; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Londenberg+A%22">Londenberg A</searchLink>; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bassan+A%22">Bassan A</searchLink>; Innovatune Srl, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Cross+K%22">Cross K</searchLink>; INSTEM, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Elenschneider+L%22">Elenschneider L</searchLink>; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Escher+SE%22">Escher SE</searchLink>; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Fahrer+J%22">Fahrer J</searchLink>; Division of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Kaiserslautern, Germany.<br /><searchLink fieldCode="AU" term="%22Fangmann+J%22">Fangmann J</searchLink>; LiverCenter Hannover (LCH), KRH Klinikum Region Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Felske+C%22">Felske C</searchLink>; Division of Food Chemistry and Toxicology, Department of Chemistry, Rheinland-Pfälzische Technische Universität (RPTU) Kaiserslautern-Landau, Kaiserslautern, Germany.<br /><searchLink fieldCode="AU" term="%22Frötschl+R%22">Frötschl R</searchLink>; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Haas+B%22">Haas B</searchLink>; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Johnson+GE%22">Johnson GE</searchLink>; Swansea University Medical School, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Vogel+M%22">Vogel M</searchLink>; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Whomsley+R%22">Whomsley R</searchLink>; European Medicines Agency, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Ziemann+C%22">Ziemann C</searchLink>; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany. christina.ziemann@item.fraunhofer.de.
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              Text: 2026 Jun 02
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