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Using routinely collected data for research purposes: challenges and mitigation strategies.

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Title: Using routinely collected data for research purposes: challenges and mitigation strategies.
Authors: Hoffmann S; Department of Statistics, Ludwig Maximilian University, Munich, Germany sabine.hoffmann@stat.uni-muenchen.de., Morris T; MRC Clinical Trials Unit at UCL, London, UK., Herrmann M; Institute for Medical Information Processing, Biometry and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.; Munich Center for Machine Learning (MCML), Munich, Germany., Heinze G; Institute of Clinical Biometrics, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria., Wynants L; Department of Epidemiology, Care and Public Health Research Institute, Maastricht University, Netherlands.; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Leuven Unit of Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium., Van Calster B; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Leuven Unit of Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium., Bischl B; Department of Statistics, Ludwig Maximilian University, Munich, Germany.; Munich Center for Machine Learning (MCML), Munich, Germany., Schmid M; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Shaw PA; Biostatistics Unit, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Mathes T; Department of Medical Statistics, University Medical Center Goettingen, Germany.; Institute for Quality and Efficacy in Health Care, Cologne, Germany., Naudet F; University of Rennes CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail), Rennes, France.; Institut Universitaire de France (IUF), Paris, France., Harrell FE; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA., Niethammer M; Department of Statistics, Ludwig Maximilian University, Munich, Germany., Muli S; Institute of Nutrition and Food Sciences (IEL) -Nutritional Epidemiology, University of Bonn, Bonn, Germany., Zimmer S; Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany., Bakhtiary F; Department of Cardiac Surgery, University Hospital Bonn, Bonn, Germany., Leistner D; Department of Cardiology/Angiology, University Heart Center Frankfurt, Goethe University Hospital, Frankfurt, Germany., Schulze PC; Klinik für Innere Medizin I, Universitätsklinikum Jena, Jena, Germany., Sedding D; Mid-German Heart Center, Department of Cardiology and Intensive Care Medicine, University Hospital, Halle (Saale), Germany., Lurz P; Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany., Rassaf T; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Germany., Kelm M; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Baldus S; Department III of Internal Medicine, Heart Center, University of Cologne, Cologne, Germany., Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Nickenig G; Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany., Thiele H; Department of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany., Lüsebrink E; Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany.
Source: BMJ (Clinical research ed.) [BMJ] 2026 Jun 02; Vol. 393, pp. e087812. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Association Country of Publication: England NLM ID: 8900488 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-1833 (Electronic) Linking ISSN: 09598138 NLM ISO Abbreviation: BMJ Subsets: MEDLINE; In Process
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  Data: <searchLink fieldCode="AU" term="%22Hoffmann+S%22">Hoffmann S</searchLink>; Department of Statistics, Ludwig Maximilian University, Munich, Germany sabine.hoffmann@stat.uni-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Morris+T%22">Morris T</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Herrmann+M%22">Herrmann M</searchLink>; Institute for Medical Information Processing, Biometry and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.; Munich Center for Machine Learning (MCML), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heinze+G%22">Heinze G</searchLink>; Institute of Clinical Biometrics, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wynants+L%22">Wynants L</searchLink>; Department of Epidemiology, Care and Public Health Research Institute, Maastricht University, Netherlands.; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Leuven Unit of Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Calster+B%22">Van Calster B</searchLink>; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Leuven Unit of Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Bischl+B%22">Bischl B</searchLink>; Department of Statistics, Ludwig Maximilian University, Munich, Germany.; Munich Center for Machine Learning (MCML), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+M%22">Schmid M</searchLink>; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Shaw+PA%22">Shaw PA</searchLink>; Biostatistics Unit, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mathes+T%22">Mathes T</searchLink>; Department of Medical Statistics, University Medical Center Goettingen, Germany.; Institute for Quality and Efficacy in Health Care, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Naudet+F%22">Naudet F</searchLink>; University of Rennes CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail), Rennes, France.; Institut Universitaire de France (IUF), Paris, France.<br /><searchLink fieldCode="AU" term="%22Harrell+FE%22">Harrell FE</searchLink>; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Niethammer+M%22">Niethammer M</searchLink>; Department of Statistics, Ludwig Maximilian University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Muli+S%22">Muli S</searchLink>; Institute of Nutrition and Food Sciences (IEL) -Nutritional Epidemiology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Zimmer+S%22">Zimmer S</searchLink>; Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Bakhtiary+F%22">Bakhtiary F</searchLink>; Department of Cardiac Surgery, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Leistner+D%22">Leistner D</searchLink>; Department of Cardiology/Angiology, University Heart Center Frankfurt, Goethe University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+PC%22">Schulze PC</searchLink>; Klinik für Innere Medizin I, Universitätsklinikum Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Sedding+D%22">Sedding D</searchLink>; Mid-German Heart Center, Department of Cardiology and Intensive Care Medicine, University Hospital, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Lurz+P%22">Lurz P</searchLink>; Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Rassaf+T%22">Rassaf T</searchLink>; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kelm+M%22">Kelm M</searchLink>; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Baldus+S%22">Baldus S</searchLink>; Department III of Internal Medicine, Heart Center, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bauersachs+J%22">Bauersachs J</searchLink>; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Nickenig+G%22">Nickenig G</searchLink>; Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Thiele+H%22">Thiele H</searchLink>; Department of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Lüsebrink+E%22">Lüsebrink E</searchLink>; Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany.
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  Data: <searchLink fieldCode="JN" term="%228900488%22">BMJ (Clinical research ed.)</searchLink> [BMJ] 2026 Jun 02; Vol. 393, pp. e087812. <i>Date of Electronic Publication: </i>2026 Jun 02.
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