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Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice.

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Title: Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice.
Authors: Onda DA; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Yang CH; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Goldsmith C; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia., Beddows CA; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia., Teo RQ; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia., Zhang L; St Vincent's Center for Applied Medical Research, Sydney, NSW, Australia., Yuan X; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Zhu Y; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Lee MK; Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia., Ovens AJ; Protein Engineering in Immunity & Metabolism, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Yu D; St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Sakamoto K; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Scott JW; St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Melbourne, Victoria, Australia., Murphy AJ; Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Diabetes, Monash University, Melbourne, Australia; Department of Cardiometabolic Health, University of Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Tsumaki N; Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan., Herzog H; St Vincent's Center for Applied Medical Research, Sydney, NSW, Australia., Dodd GT; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia., Loh K; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. kloh@svi.edu.au.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia. kloh@svi.edu.au.; Mary MacKillop Institute for Health Research, Australian Catholic University, Victoria, Australia. kloh@svi.edu.au.
Source: Nature communications [Nat Commun] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Onda+DA%22">Onda DA</searchLink>; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yang+CH%22">Yang CH</searchLink>; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Goldsmith+C%22">Goldsmith C</searchLink>; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Beddows+CA%22">Beddows CA</searchLink>; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Teo+RQ%22">Teo RQ</searchLink>; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; St Vincent's Center for Applied Medical Research, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Yuan+X%22">Yuan X</searchLink>; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+MK%22">Lee MK</searchLink>; Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Ovens+AJ%22">Ovens AJ</searchLink>; Protein Engineering in Immunity & Metabolism, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yu+D%22">Yu D</searchLink>; St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sakamoto+K%22">Sakamoto K</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Scott+JW%22">Scott JW</searchLink>; St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Murphy+AJ%22">Murphy AJ</searchLink>; Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Diabetes, Monash University, Melbourne, Australia; Department of Cardiometabolic Health, University of Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Tsumaki+N%22">Tsumaki N</searchLink>; Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Herzog+H%22">Herzog H</searchLink>; St Vincent's Center for Applied Medical Research, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dodd+GT%22">Dodd GT</searchLink>; Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Loh+K%22">Loh K</searchLink>; Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. kloh@svi.edu.au.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia. kloh@svi.edu.au.; Mary MacKillop Institute for Health Research, Australian Catholic University, Victoria, Australia. kloh@svi.edu.au.
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