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DREAM repressive activity links somatic mutation, lifespan and disease.

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Title: DREAM repressive activity links somatic mutation, lifespan and disease.
Authors: Koch Z; Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA., Nandi SP; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Licon K; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Bujarrabal-Dueso A; Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Meyer DH; Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Saeed S; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Perampalam P; Department of Pathology and Laboratory Medicine, Verspeeten Family Cancer Centre, Children's Health Research Institute, Western University, London, Ontario, Canada., Dick FA; Department of Pathology and Laboratory Medicine, Verspeeten Family Cancer Centre, Children's Health Research Institute, Western University, London, Ontario, Canada., Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Alexandrov LB; Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Ideker T; Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA. tideker@health.ucsd.edu.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. tideker@health.ucsd.edu.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA. tideker@health.ucsd.edu.
Source: Nature aging [Nat Aging] 2026 Jun; Vol. 6 (6), pp. 1267-1280. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DREAM repressive activity links somatic mutation, lifespan and disease.
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  Data: <searchLink fieldCode="AU" term="%22Koch+Z%22">Koch Z</searchLink>; Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nandi+SP%22">Nandi SP</searchLink>; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Licon+K%22">Licon K</searchLink>; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bujarrabal-Dueso+A%22">Bujarrabal-Dueso A</searchLink>; Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Meyer+DH%22">Meyer DH</searchLink>; Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Saeed+S%22">Saeed S</searchLink>; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perampalam+P%22">Perampalam P</searchLink>; Department of Pathology and Laboratory Medicine, Verspeeten Family Cancer Centre, Children's Health Research Institute, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dick+FA%22">Dick FA</searchLink>; Department of Pathology and Laboratory Medicine, Verspeeten Family Cancer Centre, Children's Health Research Institute, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Schumacher+B%22">Schumacher B</searchLink>; Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Alexandrov+LB%22">Alexandrov LB</searchLink>; Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ideker+T%22">Ideker T</searchLink>; Program in Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, CA, USA. tideker@health.ucsd.edu.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. tideker@health.ucsd.edu.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA. tideker@health.ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Jun; Vol. 6 (6), pp. 1267-1280. <i>Date of Electronic Publication: </i>2026 Jun 02.
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              Text: 2026 Jun
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