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Therapeutic Targeting of IL-17A-Driven PTGS2/NLRP3 Inflammasome Activation in Juvenile Myelomonocytic Leukemia.

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Title: Therapeutic Targeting of IL-17A-Driven PTGS2/NLRP3 Inflammasome Activation in Juvenile Myelomonocytic Leukemia.
Authors: Pasupuleti SK; Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States., Ramdas B; Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States., Padam KSR; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States., Kanumuri R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States., Palam LR; Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States., Kumar R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States., Ho TC; Indiana University School of Medicine, Indianapolis, Indiana, United States., Lee AG; University California San Francisco, San Francisco, California, United States., Clapp W; Indiana University School of Medicine, Indianapolis, Indiana, United States., Qu CK; Emory University School of Medicine, Atlanta, Georgia, United States., Stieglitz E; UCSF Benioff Children's Hospitals, San Francisco, California, United States., Yang K; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States., Kapur R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Source: Blood [Blood] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Therapeutic Targeting of IL-17A-Driven PTGS2/NLRP3 Inflammasome Activation in Juvenile Myelomonocytic Leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Pasupuleti+SK%22">Pasupuleti SK</searchLink>; Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Ramdas+B%22">Ramdas B</searchLink>; Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Padam+KSR%22">Padam KSR</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Kanumuri+R%22">Kanumuri R</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Palam+LR%22">Palam LR</searchLink>; Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Ho+TC%22">Ho TC</searchLink>; Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Lee+AG%22">Lee AG</searchLink>; University California San Francisco, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Clapp+W%22">Clapp W</searchLink>; Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Qu+CK%22">Qu CK</searchLink>; Emory University School of Medicine, Atlanta, Georgia, United States.<br /><searchLink fieldCode="AU" term="%22Stieglitz+E%22">Stieglitz E</searchLink>; UCSF Benioff Children's Hospitals, San Francisco, California, United States.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.<br /><searchLink fieldCode="AU" term="%22Kapur+R%22">Kapur R</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
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  Data: <searchLink fieldCode="JN" term="%227603509%22">Blood</searchLink> [Blood] 2026 Jun 02. <i>Date of Electronic Publication: </i>2026 Jun 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1182/blood.2025032588
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      – Code: eng
        Text: English
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      – TitleFull: Therapeutic Targeting of IL-17A-Driven PTGS2/NLRP3 Inflammasome Activation in Juvenile Myelomonocytic Leukemia.
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              Text: 2026 Jun 02
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