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DICER-driven regulation of lipid metabolism and macrophage-adipocyte crosstalk in partial lipodystrophy.

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Title: DICER-driven regulation of lipid metabolism and macrophage-adipocyte crosstalk in partial lipodystrophy.
Authors: Rocha AL; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA., Godoi R; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., de Lima TI; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil., de Moraes D; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Brandão BB; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Pinto AFM; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA; Mass Spectrometry Core for Proteomics and Metabolomics, The Salk Institute for Biological Studies, La Jolla, CA, USA., Braz-de-Melo HA; Department of Cell Biology, Institute of Biological Sciences, Universidade de Brasilia, Brasilia, DF, Brazil., da Silva FC; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Gonçalves TT; Department of Pharmacology, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil., Figueiredo LS; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Morphofunctional and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Mazzi JP; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Morphofunctional and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., de Lima Junior NC; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Sousa SML; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Miyamoto JE; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Leiria LO; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Kornfeld JW; Functional Genomics and Metabolism Research Unit, Institute of Biochemistry and Molecular Biology, Faculty of Science, University of Southern Denmark, Odense, Denmark; Novo Nordisk Foundation Center for Adipocyte Signaling, University of Southern Denmark, Odense, Denmark., Magalhães KG; Department of Cell Biology, Institute of Biological Sciences, Universidade de Brasilia, Brasilia, DF, Brazil., Moraes-Vieira PM; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), Universidade Estadual de Campinas, Campinas, SP, Brazil., Saghatelian A; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA; Mass Spectrometry Core for Proteomics and Metabolomics, The Salk Institute for Biological Studies, La Jolla, CA, USA., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Morphofunctional and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address: morima@unicamp.br.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jul; Vol. 200, pp. 119548. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: DICER-driven regulation of lipid metabolism and macrophage-adipocyte crosstalk in partial lipodystrophy.
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  Data: <searchLink fieldCode="AU" term="%22Rocha+AL%22">Rocha AL</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Godoi+R%22">Godoi R</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Lima+TI%22">de Lima TI</searchLink>; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Moraes+D%22">de Moraes D</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Brandão+BB%22">Brandão BB</searchLink>; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pinto+AFM%22">Pinto AFM</searchLink>; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA; Mass Spectrometry Core for Proteomics and Metabolomics, The Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Braz-de-Melo+HA%22">Braz-de-Melo HA</searchLink>; Department of Cell Biology, Institute of Biological Sciences, Universidade de Brasilia, Brasilia, DF, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+FC%22">da Silva FC</searchLink>; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+TT%22">Gonçalves TT</searchLink>; Department of Pharmacology, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Figueiredo+LS%22">Figueiredo LS</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Morphofunctional and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Mazzi+JP%22">Mazzi JP</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Morphofunctional and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Lima+Junior+NC%22">de Lima Junior NC</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+SML%22">Sousa SML</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Miyamoto+JE%22">Miyamoto JE</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Leiria+LO%22">Leiria LO</searchLink>; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Kornfeld+JW%22">Kornfeld JW</searchLink>; Functional Genomics and Metabolism Research Unit, Institute of Biochemistry and Molecular Biology, Faculty of Science, University of Southern Denmark, Odense, Denmark; Novo Nordisk Foundation Center for Adipocyte Signaling, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Magalhães+KG%22">Magalhães KG</searchLink>; Department of Cell Biology, Institute of Biological Sciences, Universidade de Brasilia, Brasilia, DF, Brazil.<br /><searchLink fieldCode="AU" term="%22Moraes-Vieira+PM%22">Moraes-Vieira PM</searchLink>; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Saghatelian+A%22">Saghatelian A</searchLink>; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA; Mass Spectrometry Core for Proteomics and Metabolomics, The Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mori+MA%22">Mori MA</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil; Program in Morphofunctional and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address: morima@unicamp.br.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 Jul; Vol. 200, pp. 119548. <i>Date of Electronic Publication: </i>2026 Jun 03.
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