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Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network.

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Title: Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network.
Authors: Yinuo W; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Toyama T; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. Electronic address: takashi.toyama.c6@tohoku.ac.jp., Yamakoshi H; Laboratory of Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Taguchi H; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan; Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Takashima H; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Watanabe R; Laboratory of Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Mita Y; The Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan., Ito J; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 1-85764 Neuherberg, Bavaria, 85764, Germany; Laboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki, Aoba-ku Sendai, 980-8572, Japan., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 1-85764 Neuherberg, Bavaria, 85764, Germany; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Akiyama Y; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Shibata H; Department of Clinical Oncology, Graduate School of Medicine, Akita University, 1-1-1 Hondo, Akita, 010-8543, Japan., Noguchi N; The Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan., Takamura T; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, 920-8640, Japan., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 1-85764 Neuherberg, Bavaria, 85764, Germany; Translational Redox Biology, Natural School of Sciences, Technical University of Munich, Garching, 85748, Germany., Tomikoka Y; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Iwabuchi Y; Laboratory of Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Saito Y; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. Electronic address: yoshiro.saito.a8@tohoku.ac.jp.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Jun 02; Vol. 253, pp. 487-499. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
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  Data: Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network.
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  Data: <searchLink fieldCode="AU" term="%22Yinuo+W%22">Yinuo W</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Toyama+T%22">Toyama T</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. Electronic address: takashi.toyama.c6@tohoku.ac.jp.<br /><searchLink fieldCode="AU" term="%22Yamakoshi+H%22">Yamakoshi H</searchLink>; Laboratory of Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Taguchi+H%22">Taguchi H</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan; Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Takashima+H%22">Takashima H</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+R%22">Watanabe R</searchLink>; Laboratory of Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Mita+Y%22">Mita Y</searchLink>; The Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+J%22">Ito J</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 1-85764 Neuherberg, Bavaria, 85764, Germany; Laboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki, Aoba-ku Sendai, 980-8572, Japan.<br /><searchLink fieldCode="AU" term="%22Mishima+E%22">Mishima E</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 1-85764 Neuherberg, Bavaria, 85764, Germany; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Akiyama+Y%22">Akiyama Y</searchLink>; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Shibata+H%22">Shibata H</searchLink>; Department of Clinical Oncology, Graduate School of Medicine, Akita University, 1-1-1 Hondo, Akita, 010-8543, Japan.<br /><searchLink fieldCode="AU" term="%22Noguchi+N%22">Noguchi N</searchLink>; The Systems Life Sciences laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.<br /><searchLink fieldCode="AU" term="%22Takamura+T%22">Takamura T</searchLink>; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, 920-8640, Japan.<br /><searchLink fieldCode="AU" term="%22Conrad+M%22">Conrad M</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 1-85764 Neuherberg, Bavaria, 85764, Germany; Translational Redox Biology, Natural School of Sciences, Technical University of Munich, Garching, 85748, Germany.<br /><searchLink fieldCode="AU" term="%22Tomikoka+Y%22">Tomikoka Y</searchLink>; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.<br /><searchLink fieldCode="AU" term="%22Iwabuchi+Y%22">Iwabuchi Y</searchLink>; Laboratory of Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+Y%22">Saito Y</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. Electronic address: yoshiro.saito.a8@tohoku.ac.jp.
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