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Clinical pharmacology insights from recent cell and gene therapy approvals relevant to pediatrics.

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Title: Clinical pharmacology insights from recent cell and gene therapy approvals relevant to pediatrics.
Authors: Kunanayagam S; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Wang MC; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Loucks CM; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; BC Children's Hospital Research Institute, Vancouver, BC, Canada., Garcia-Bournissen F; Division of Pediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada., Verstegen RHJ; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Lewis T; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.; Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.; Division of Neonatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.
Source: Pediatric research [Pediatr Res] 2026 Jun 03. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kunanayagam+S%22">Kunanayagam S</searchLink>; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+MC%22">Wang MC</searchLink>; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Loucks+CM%22">Loucks CM</searchLink>; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; BC Children's Hospital Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Garcia-Bournissen+F%22">Garcia-Bournissen F</searchLink>; Division of Pediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Verstegen+RHJ%22">Verstegen RHJ</searchLink>; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lewis+T%22">Lewis T</searchLink>; Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.; Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.; Division of Neonatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada. tamorah.lewis@sickkids.ca.
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  Data: <searchLink fieldCode="JN" term="%220100714%22">Pediatric research</searchLink> [Pediatr Res] 2026 Jun 03. <i>Date of Electronic Publication: </i>2026 Jun 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0100714 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1530-0447 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200313998%22">00313998 </searchLink><i>NLM ISO Abbreviation: </i>Pediatr Res <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41390-026-05138-6
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      – Code: eng
        Text: English
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      – TitleFull: Clinical pharmacology insights from recent cell and gene therapy approvals relevant to pediatrics.
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            – D: 03
              M: 06
              Text: 2026 Jun 03
              Type: published
              Y: 2026
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