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Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.

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Title: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.
Authors: Ghannam JY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard/MIT MD-PhD Program and Harvard Immunology PhD Program, Harvard Medical School, Boston, MA, USA., Bryan J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Weiss J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kovarsky D; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Merrell D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Messer C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schlueter-Kuck K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fell GG; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Lim-Fat MJ; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Youssef G; Harvard Medical School, Boston, MA, USA.; Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rahman R; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA., Qin L; Department of Imaging, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA., Young GS; Departments of Radiology, Mass General Brigham, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA., Janes JT 3rd; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Van Orden M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Gans A; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lin ES; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Huang RY; Departments of Radiology, Mass General Brigham, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA., Danysh BP; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Parida L; IBM Research, Yorktown Heights, NY, USA., Li S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Wen PY; Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Chiocca EA; Center for Tumors of the Nervous System, Mass General Brigham Cancer Institute & Department of Neurosurgery, Mass General Brigham, Boston, MA, USA., Neuberg D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Ligon KL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Tirosh I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Reardon DA; Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Getz G; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. catherine_wu@dfci.harvard.edu.
Source: Nature cancer [Nat Cancer] 2026 Jun 03. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Ghannam+JY%22">Ghannam JY</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard/MIT MD-PhD Program and Harvard Immunology PhD Program, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bryan+J%22">Bryan J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+J%22">Weiss J</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kovarsky+D%22">Kovarsky D</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Merrell+D%22">Merrell D</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Messer+C%22">Messer C</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schlueter-Kuck+K%22">Schlueter-Kuck K</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fell+GG%22">Fell GG</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lim-Fat+MJ%22">Lim-Fat MJ</searchLink>; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Youssef+G%22">Youssef G</searchLink>; Harvard Medical School, Boston, MA, USA.; Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+R%22">Rahman R</searchLink>; 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Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+PY%22">Wen PY</searchLink>; Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chiocca+EA%22">Chiocca EA</searchLink>; Center for Tumors of the Nervous System, Mass General Brigham Cancer Institute & Department of Neurosurgery, Mass General Brigham, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Neuberg+D%22">Neuberg D</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ligon+KL%22">Ligon KL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tirosh+I%22">Tirosh I</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Reardon+DA%22">Reardon DA</searchLink>; Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Getz+G%22">Getz G</searchLink>; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+CJ%22">Wu CJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. catherine_wu@dfci.harvard.edu.
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