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Phenotypic Response Surfaces-Guided Optimization (PRS-OPT) of Propolis-Metformin-Regorafenib Combination Therapy for MASLD-Associated Hepatocellular Carcinoma.

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Title: Phenotypic Response Surfaces-Guided Optimization (PRS-OPT) of Propolis-Metformin-Regorafenib Combination Therapy for MASLD-Associated Hepatocellular Carcinoma.
Authors: Huang YS; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Ma CY; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Roan HY; Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan., Chiang CH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan., Tsou HH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan., Chen CH; Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan., Lin YF; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Wang HD; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan., Yuh CH; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Source: Oncology research [Oncol Res] 2026 May 21; Vol. 34 (6), pp. 25. Date of Electronic Publication: 2026 May 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Tech Science Press Country of Publication: United States NLM ID: 9208097 Publication Model: eCollection Cited Medium: Internet ISSN: 1555-3906 (Electronic) Linking ISSN: 09650407 NLM ISO Abbreviation: Oncol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phenotypic Response Surfaces-Guided Optimization (PRS-OPT) of Propolis-Metformin-Regorafenib Combination Therapy for MASLD-Associated Hepatocellular Carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Huang+YS%22">Huang YS</searchLink>; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ma+CY%22">Ma CY</searchLink>; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Roan+HY%22">Roan HY</searchLink>; Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+CH%22">Chiang CH</searchLink>; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsou+HH%22">Tsou HH</searchLink>; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HD%22">Wang HD</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuh+CH%22">Yuh CH</searchLink>; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan.; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%229208097%22">Oncology research</searchLink> [Oncol Res] 2026 May 21; Vol. 34 (6), pp. 25. <i>Date of Electronic Publication: </i>2026 May 21 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Tech+Science+Press%22">Tech Science Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9208097 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1555-3906 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209650407%22">09650407 </searchLink><i>NLM ISO Abbreviation: </i>Oncol Res <i>Subsets: </i>MEDLINE
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        Value: 10.32604/or.2026.074145
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        Text: English
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      – TitleFull: Phenotypic Response Surfaces-Guided Optimization (PRS-OPT) of Propolis-Metformin-Regorafenib Combination Therapy for MASLD-Associated Hepatocellular Carcinoma.
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              Text: 2026 May 21
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