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A Model-Informed Early Prediction of Methotrexate-Induced Acute Kidney Injury in Pediatric Patients with Osteosarcoma Using Real-World Data: A Multi-center Pharmacokinetic Study.

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Title: A Model-Informed Early Prediction of Methotrexate-Induced Acute Kidney Injury in Pediatric Patients with Osteosarcoma Using Real-World Data: A Multi-center Pharmacokinetic Study.
Authors: Rega P; Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay., Vallespin JM; Department of Pharmacy, Hospital Calvo Mackenna, Santiago de Chile, Chile., Aldaz A; Department of Pharmacy, Clinica Universidad de Navarra, Navarra, Spain., Pappas A; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Guido PC; Unit of Clinical Pharmacokinetics, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina., Azocar M; Department of Pharmacy, Hospital Calvo Mackenna, Santiago de Chile, Chile., Villarroel M; Oncology Service, Hospital Calvo Mackenna, Santiago de Chile, Chile., Pauley JL; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA., Stewart CF; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Ibarra M; Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay., Schaiquevich P; Unit of Innovative Treatments, Hospital de Pediatria JP Garrahan, Combate de los Pozos 1881, CP1245, CABA, Buenos Aires, Argentina. paulas@conicet.gov.ar.; Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Buenos Aires, Argentina. paulas@conicet.gov.ar.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 Jun 04. Date of Electronic Publication: 2026 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rega+P%22">Rega P</searchLink>; Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Vallespin+JM%22">Vallespin JM</searchLink>; Department of Pharmacy, Hospital Calvo Mackenna, Santiago de Chile, Chile.<br /><searchLink fieldCode="AU" term="%22Aldaz+A%22">Aldaz A</searchLink>; Department of Pharmacy, Clinica Universidad de Navarra, Navarra, Spain.<br /><searchLink fieldCode="AU" term="%22Pappas+A%22">Pappas A</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Guido+PC%22">Guido PC</searchLink>; Unit of Clinical Pharmacokinetics, Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Azocar+M%22">Azocar M</searchLink>; Department of Pharmacy, Hospital Calvo Mackenna, Santiago de Chile, Chile.<br /><searchLink fieldCode="AU" term="%22Villarroel+M%22">Villarroel M</searchLink>; Oncology Service, Hospital Calvo Mackenna, Santiago de Chile, Chile.<br /><searchLink fieldCode="AU" term="%22Pauley+JL%22">Pauley JL</searchLink>; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+CF%22">Stewart CF</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ibarra+M%22">Ibarra M</searchLink>; Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Schaiquevich+P%22">Schaiquevich P</searchLink>; Unit of Innovative Treatments, Hospital de Pediatria JP Garrahan, Combate de los Pozos 1881, CP1245, CABA, Buenos Aires, Argentina. paulas@conicet.gov.ar.; Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Buenos Aires, Argentina. paulas@conicet.gov.ar.
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              Text: 2026 Jun 04
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