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Diabetes-associated MYT1 and ST18 genes regulate human beta cell insulin secretion and survival via other diabetes risk genes.

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Title: Diabetes-associated MYT1 and ST18 genes regulate human beta cell insulin secretion and survival via other diabetes risk genes.
Authors: Hu R; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Hamilton N; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Wang Y; Department of Biostatistics and Center for Quantitative Sciences, Vanderbilt Medical Center, Nashville, TN, USA., Tong X; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Yagan M; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Harmelink C; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Doss TD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Liu J; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Xu Y; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Computational Systems Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Simmons AJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Computational Systems Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Lau KS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Computational Systems Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Stein R; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Balamurugan AN; Wendy Novak Diabetes Institute, Norton Children's Research Institute, Norton Healthcare, Louisville, KY, USA.; Department of Pediatrics, Division of Endocrinology, Pediatric Research Institute, University of Louisville, Louisville, KY, USA., Kaverina I; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Coate KC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Liu Q; Department of Biostatistics and Center for Quantitative Sciences, Vanderbilt Medical Center, Nashville, TN, USA., Gu G; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. Guoqiang.gu@vanderbilt.edu.
Source: Diabetologia [Diabetologia] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: Diabetes-associated MYT1 and ST18 genes regulate human beta cell insulin secretion and survival via other diabetes risk genes.
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  Data: <searchLink fieldCode="AU" term="%22Hu+R%22">Hu R</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+N%22">Hamilton N</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biostatistics and Center for Quantitative Sciences, Vanderbilt Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Tong+X%22">Tong X</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yagan+M%22">Yagan M</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Dadi+PK%22">Dadi PK</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Harmelink+C%22">Harmelink C</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Doss+TD%22">Doss TD</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Computational Systems Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+AJ%22">Simmons AJ</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Computational Systems Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lau+KS%22">Lau KS</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Computational Systems Biology, Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Stein+R%22">Stein R</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Balamurugan+AN%22">Balamurugan AN</searchLink>; Wendy Novak Diabetes Institute, Norton Children's Research Institute, Norton Healthcare, Louisville, KY, USA.; Department of Pediatrics, Division of Endocrinology, Pediatric Research Institute, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Kaverina+I%22">Kaverina I</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Coate+KC%22">Coate KC</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jacobson+DA%22">Jacobson DA</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Biostatistics and Center for Quantitative Sciences, Vanderbilt Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gu+G%22">Gu G</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. Guoqiang.gu@vanderbilt.edu.
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        Value: 10.1007/s00125-026-06757-8
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