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NPY-Y2R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence.

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Title: NPY-Y2R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence.
Authors: He ZL; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China., Xu C; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Yang QF; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China., Han CZ; School of Foreign Languages, Beihang University, Beijing 100191, China., Wu T; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China., Xu YQ; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China., Liu YZ; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China., Ni LY; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China., Jia SQ; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China., Zhang TY; Department of Human Anatomy, Histology & Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China., Wang Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address: wangy66@bjmu.edu.cn., Feng Y; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China. Electronic address: doc_yifeng@163.com.
Source: Science bulletin [Sci Bull (Beijing)] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101655530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-9281 (Electronic) Linking ISSN: 20959273 NLM ISO Abbreviation: Sci Bull (Beijing) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NPY-Y<subscript>2</subscript>R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence.
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  Data: <searchLink fieldCode="AU" term="%22He+ZL%22">He ZL</searchLink>; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China; Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yang+QF%22">Yang QF</searchLink>; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Han+CZ%22">Han CZ</searchLink>; School of Foreign Languages, Beihang University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Xu+YQ%22">Xu YQ</searchLink>; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China.<br /><searchLink fieldCode="AU" term="%22Liu+YZ%22">Liu YZ</searchLink>; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Ni+LY%22">Ni LY</searchLink>; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Jia+SQ%22">Jia SQ</searchLink>; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Zhang+TY%22">Zhang TY</searchLink>; Department of Human Anatomy, Histology & Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address: wangy66@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Anesthesiology & Department of Pain Medicine, Peking University People's Hospital and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100044, China. Electronic address: doc_yifeng@163.com.
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        Value: 10.1016/j.scib.2026.05.062
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      – TitleFull: NPY-Y2R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence.
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            – D: 28
              M: 05
              Text: 2026 May 28
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              Y: 2026
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