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DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.

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Title: DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.
Authors: Cai W; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Pohl SÖ; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Lai X; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lam HY; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Low CS; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Koh V; National University Cancer Institute Singapore, National University Health System, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ma H; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore., Agostino M; Curtin Institute for Computation, Curtin University, Perth, Australia., Banerjee A; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.; Biocon Limited, Bangalore, India., Bunnag N; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Science, Yale-NUS College, Singapore, Singapore., Suresh J; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Division of Science, Yale-NUS College, Singapore, Singapore., Deivasigamani A; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore, Singapore., Yuan Y; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Rajasekaran M; Programme in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore., Chen J; Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore, Singapore., Swa HLF; Diagnostics Development Hub, A*STAR, Singapore, Singapore., Hua SH; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Guo S; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teng JC; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chin JM; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Choy JYH; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Thike AA; Division of Pathology, Singapore General Hospital, Singapore, Singapore., Lee YB; Rexahn Pharmaceuticals Inc., Rockville, MD, USA., Kanchi MM; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Genome Sciences, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Ramesh K; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Mok YK; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Huang RY; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Gunaratne J; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Fullwood MJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, Singapore., Tan PH; Division of Pathology, Singapore General Hospital, Singapore, Singapore.; Luma Medical Centre, Singapore, Singapore., Yip GW; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Blaydes JP; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Yap CT; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lobie PE; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Tsinghua Berkeley Shenzhen Institute, Tsinghua University Graduate School at Shenzhen, Shenzhen, China., Kok VJ; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Dharmarajan A; Trichy SRM Medical College Hospital and Research Centre, Tiruchirappalli, India.; School of Human Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, Perth, Australia.; Curtin Medical School, Curtin University, Perth, WA, Australia., Hui KM; Micro Tech Health Sdn Bhd, Kuala Lumpur, Malaysia., Kim DJ; Rexahn Pharmaceuticals Inc., Rockville, MD, USA., Cheong JK; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tolwinski N; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Division of Science, Yale-NUS College, Singapore, Singapore., Yong WP; National University Cancer Institute Singapore, National University Health System, Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Tan P; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore, Singapore.; Singhealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore, Singapore., Myant KB; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Kumar AP; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. apkumar@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. apkumar@nus.edu.sg.
Source: Cell death & disease [Cell Death Dis] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
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