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Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer.

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Title: Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer.
Authors: Chen WY; Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, 11031, Taiwan.; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Huang KH; Department of Surgery, Division of Urology, Chi-Mei Medical Center, Tainan, 710, Taiwan., Kajla G; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Wen YC; Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, 11031, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, 11031, Taiwan., Liu MK; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Fan YC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Dung PVT; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Yeh HL; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Chen WH; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Jiang KC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Li HR; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan., Chen CS; School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Huang J; Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA., Beltran H; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, 02215-5450, USA., Liu YN; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan. liuy@tmu.edu.tw.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan. liuy@tmu.edu.tw.; Prostate Center of Excellence, Taipei Medical University Hospital, Taipei Medical University, Taipei, 11031, Taiwan. liuy@tmu.edu.tw.; Taipei Medical University, 301, Yuantong Road, Zhonghe District, New Taipei City, 234, Taiwan. liuy@tmu.edu.tw.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Jun 08. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chen+WY%22">Chen WY</searchLink>; Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, 11031, Taiwan.; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KH%22">Huang KH</searchLink>; Department of Surgery, Division of Urology, Chi-Mei Medical Center, Tainan, 710, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kajla+G%22">Kajla G</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wen+YC%22">Wen YC</searchLink>; Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, 11031, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+MK%22">Liu MK</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fan+YC%22">Fan YC</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Dung+PVT%22">Dung PVT</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+HL%22">Yeh HL</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WH%22">Chen WH</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+KC%22">Jiang KC</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+HR%22">Li HR</searchLink>; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CS%22">Chen CS</searchLink>; School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Beltran+H%22">Beltran H</searchLink>; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, 02215-5450, USA.<br /><searchLink fieldCode="AU" term="%22Liu+YN%22">Liu YN</searchLink>; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan. liuy@tmu.edu.tw.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City, 235, Taiwan. liuy@tmu.edu.tw.; Prostate Center of Excellence, Taipei Medical University Hospital, Taipei Medical University, Taipei, 11031, Taiwan. liuy@tmu.edu.tw.; Taipei Medical University, 301, Yuantong Road, Zhonghe District, New Taipei City, 234, Taiwan. liuy@tmu.edu.tw.
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        Value: 10.1186/s12964-026-02977-y
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      – Code: eng
        Text: English
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      – TitleFull: Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer.
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            – D: 08
              M: 06
              Text: 2026 Jun 08
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