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An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2.

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Title: An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2.
Authors: Schultebraucks K; Department of Psychiatry, NYU Grossman School of Medicine, New York, USA.; Division of Healthcare Delivery Science, Department of Population Health, NYU Grossman School of Medicine, New York, USA., Gershov S; Department of Psychiatry, NYU Grossman School of Medicine, New York, USA., Fischer F; Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik Mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Germany.; German Center for Mental Health, Partner Site Berlin/Potsdam, Germany., Wingenfeld K; Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany., Schmidt S; Clinical Trial Unit of the Clinical Study Center (CSC), Berlin Institute of Health (BIH), Germany., Steinbrecher S; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany., Zoller T; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany., Steinbeis F; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany., Pütz SM; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany., Deckert J; Department of Psychiatry, University Hospital Würzburg, Germany., Scherer M; Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany.; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany., Bröhl I; Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany., Wagner P; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany., Appel KS; Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany., Kohls M; Institute for Clinical Epidemiology and Biometry, University Hospital Würzburg, Germany., Jiru-Hillmann S; Institute for Clinical Epidemiology and Biometry, University Hospital Würzburg, Germany., Nauck M; Klinische Chemie und Laboratoriumsmedizin, University Medicine Greifswald, Germany., Lorenz-Depiereux B; Institute of Epidemiology, Research Unit Molecular Epidemiology, Helmholtz Munich, Germany., Blaschke S; Emergency Department, University Medical Center Göttingen, Germany., Muzalyova A; Institute for Digital Medicine, University of Augsburg, Germany., Stellbrink C; Department of Cardiology, Universitäty Medical Center Bielefeld, Germany., Steinmetz A; Department of Orthopaedics, Trauma and Rehabilitation Medicine, Universitätsmedizin Greifswald, Germany., Addo MM; Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf, Germany., Dahl E; RWTH Centralized Biomaterial Bank (RWTH CBMB) at the Institute of Pathology, RWTH Aachen University, Germany., Zettler M; Institute of Infectiology, University Medical Center Essen, Germany., Hansch S; Department for Infectious Diseases and Infection Control, University Hospital Regensburg, Germany., Dinkel A; Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technichal University of Munich, Germany., Keitel V; Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Otto von Guericke University Magdeburg, Germany., Vehreschild MJGT; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany., Vehreschild JJ; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany.; Institute of Epidemiology, Research Unit Molecular Epidemiology, Helmholtz Munich, Germany.; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany., Paul F; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Germany., Witzenrath M; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany.; German Center for Lung Research (DZL), Partner Site Berlin, Germany., Rose M; Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik Mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Germany.; German Center for Mental Health, Partner Site Berlin/Potsdam, Germany., Otte C; Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany.; German Center for Mental Health, Partner Site Berlin/Potsdam, Germany.
Source: Brain, behavior, & immunity - health [Brain Behav Immun Health] 2026 May 20; Vol. 54, pp. 101267. Date of Electronic Publication: 2026 May 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101759062 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3546 (Electronic) Linking ISSN: 26663546 NLM ISO Abbreviation: Brain Behav Immun Health Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2.
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  Data: <searchLink fieldCode="AU" term="%22Schultebraucks+K%22">Schultebraucks K</searchLink>; Department of Psychiatry, NYU Grossman School of Medicine, New York, USA.; Division of Healthcare Delivery Science, Department of Population Health, NYU Grossman School of Medicine, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gershov+S%22">Gershov S</searchLink>; Department of Psychiatry, NYU Grossman School of Medicine, New York, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+F%22">Fischer F</searchLink>; Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik Mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Germany.; German Center for Mental Health, Partner Site Berlin/Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Wingenfeld+K%22">Wingenfeld K</searchLink>; Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+S%22">Schmidt S</searchLink>; Clinical Trial Unit of the Clinical Study Center (CSC), Berlin Institute of Health (BIH), Germany.<br /><searchLink fieldCode="AU" term="%22Steinbrecher+S%22">Steinbrecher S</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zoller+T%22">Zoller T</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbeis+F%22">Steinbeis F</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pütz+SM%22">Pütz SM</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Deckert+J%22">Deckert J</searchLink>; Department of Psychiatry, University Hospital Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Scherer+M%22">Scherer M</searchLink>; Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany.; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Bröhl+I%22">Bröhl I</searchLink>; Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+P%22">Wagner P</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Appel+KS%22">Appel KS</searchLink>; Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kohls+M%22">Kohls M</searchLink>; Institute for Clinical Epidemiology and Biometry, University Hospital Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jiru-Hillmann+S%22">Jiru-Hillmann S</searchLink>; Institute for Clinical Epidemiology and Biometry, University Hospital Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nauck+M%22">Nauck M</searchLink>; Klinische Chemie und Laboratoriumsmedizin, University Medicine Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenz-Depiereux+B%22">Lorenz-Depiereux B</searchLink>; Institute of Epidemiology, Research Unit Molecular Epidemiology, Helmholtz Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Blaschke+S%22">Blaschke S</searchLink>; Emergency Department, University Medical Center Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Muzalyova+A%22">Muzalyova A</searchLink>; Institute for Digital Medicine, University of Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stellbrink+C%22">Stellbrink C</searchLink>; Department of Cardiology, Universitäty Medical Center Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Steinmetz+A%22">Steinmetz A</searchLink>; Department of Orthopaedics, Trauma and Rehabilitation Medicine, Universitätsmedizin Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Addo+MM%22">Addo MM</searchLink>; Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf, Germany.<br /><searchLink fieldCode="AU" term="%22Dahl+E%22">Dahl E</searchLink>; RWTH Centralized Biomaterial Bank (RWTH CBMB) at the Institute of Pathology, RWTH Aachen University, Germany.<br /><searchLink fieldCode="AU" term="%22Zettler+M%22">Zettler M</searchLink>; Institute of Infectiology, University Medical Center Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hansch+S%22">Hansch S</searchLink>; Department for Infectious Diseases and Infection Control, University Hospital Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dinkel+A%22">Dinkel A</searchLink>; Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technichal University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Keitel+V%22">Keitel V</searchLink>; Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Otto von Guericke University Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vehreschild+MJGT%22">Vehreschild MJGT</searchLink>; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Vehreschild+JJ%22">Vehreschild JJ</searchLink>; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany.; Institute of Epidemiology, Research Unit Molecular Epidemiology, Helmholtz Munich, Germany.; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Paul+F%22">Paul F</searchLink>; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Witzenrath+M%22">Witzenrath M</searchLink>; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany.; German Center for Lung Research (DZL), Partner Site Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rose+M%22">Rose M</searchLink>; Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik Mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Germany.; German Center for Mental Health, Partner Site Berlin/Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Otte+C%22">Otte C</searchLink>; Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany.; German Center for Mental Health, Partner Site Berlin/Potsdam, Germany.
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