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Tumor-derived sphingosine-1-phosphate shapes angiogenesis in the acidic microenvironment of osteosarcoma via paracrine and autocrine signaling.

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Title: Tumor-derived sphingosine-1-phosphate shapes angiogenesis in the acidic microenvironment of osteosarcoma via paracrine and autocrine signaling.
Authors: Avnet S; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy., Bozzini N; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy., Nguyen PN; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy., Lipreri MV; Biomedical Science, Technology and Nanobiotechnology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Perut F; Biomedical Science, Technology and Nanobiotechnology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Baldini N; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.; Biomedical Science, Technology and Nanobiotechnology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Cortini M; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.
Source: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2026 May 21; Vol. 14, pp. 1831997. Date of Electronic Publication: 2026 May 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Tumor-derived sphingosine-1-phosphate shapes angiogenesis in the acidic microenvironment of osteosarcoma via paracrine and autocrine signaling.
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  Data: <searchLink fieldCode="AU" term="%22Avnet+S%22">Avnet S</searchLink>; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bozzini+N%22">Bozzini N</searchLink>; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Nguyen+PN%22">Nguyen PN</searchLink>; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Lipreri+MV%22">Lipreri MV</searchLink>; Biomedical Science, Technology and Nanobiotechnology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Perut+F%22">Perut F</searchLink>; Biomedical Science, Technology and Nanobiotechnology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Baldini+N%22">Baldini N</searchLink>; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.; Biomedical Science, Technology and Nanobiotechnology Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cortini+M%22">Cortini M</searchLink>; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101630250%22">Frontiers in cell and developmental biology</searchLink> [Front Cell Dev Biol] 2026 May 21; Vol. 14, pp. 1831997. <i>Date of Electronic Publication: </i>2026 May 21 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2EA%22">Frontiers Media S.A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101630250 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2296-634X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222296634X%22">2296634X </searchLink><i>NLM ISO Abbreviation: </i>Front Cell Dev Biol <i>Subsets: </i>PubMed not MEDLINE
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