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Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.

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Title: Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.
Authors: Kim EJ; Genentech South San Francisco, California United States., Jin DX; Foundation Medicine Cambridge, MA United States., Chibly AM; Genentech South San Francisco, CA United States., Dorighi K; Genentech South San Francisco, California United States., Sivakumar S; Foundation Medicine Cambridge, MA United States., Kamm J; Genentech South San Francisco, California United States., Juszkiewicz S; Genentech South San Francisco, California United States., Cabrera K; Foundation Medicine Boston, MA United States., Reja R; Genentech South San Francisco, California United States., Wang Y; Genentech South San Francisco, California United States., Nakagawa R; Genentech South San Francisco, California United States., Shi M; Genentech South San Francisco United States., Liang Y; Genentech South San Francisco, CA United States., Dey A; Genentech South San Francisco, CA United States., Sokol ES; Foundation Medicine Boston, Massachusetts United States., Gendreau S; Genentech South San Francisco, CA United States., He M; Genentech South San Francisco, California United States.
Source: Cancer research [Cancer Res] 2026 Jun 08. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.
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  Data: <searchLink fieldCode="AU" term="%22Kim+EJ%22">Kim EJ</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Jin+DX%22">Jin DX</searchLink>; Foundation Medicine Cambridge, MA United States.<br /><searchLink fieldCode="AU" term="%22Chibly+AM%22">Chibly AM</searchLink>; Genentech South San Francisco, CA United States.<br /><searchLink fieldCode="AU" term="%22Dorighi+K%22">Dorighi K</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Sivakumar+S%22">Sivakumar S</searchLink>; Foundation Medicine Cambridge, MA United States.<br /><searchLink fieldCode="AU" term="%22Kamm+J%22">Kamm J</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Juszkiewicz+S%22">Juszkiewicz S</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Cabrera+K%22">Cabrera K</searchLink>; Foundation Medicine Boston, MA United States.<br /><searchLink fieldCode="AU" term="%22Reja+R%22">Reja R</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Nakagawa+R%22">Nakagawa R</searchLink>; Genentech South San Francisco, California United States.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Genentech South San Francisco United States.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Genentech South San Francisco, CA United States.<br /><searchLink fieldCode="AU" term="%22Dey+A%22">Dey A</searchLink>; Genentech South San Francisco, CA United States.<br /><searchLink fieldCode="AU" term="%22Sokol+ES%22">Sokol ES</searchLink>; Foundation Medicine Boston, Massachusetts United States.<br /><searchLink fieldCode="AU" term="%22Gendreau+S%22">Gendreau S</searchLink>; Genentech South San Francisco, CA United States.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; Genentech South San Francisco, California United States.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2026 Jun 08. <i>Date of Electronic Publication: </i>2026 Jun 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/0008-5472.CAN-25-3977
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      – Code: eng
        Text: English
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      – TitleFull: Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.
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              Text: 2026 Jun 08
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              Y: 2026
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