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Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation.

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Title: Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation.
Authors: Nogimori T; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan., Okina Y; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan., Masuta Y; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan., Kumamoto M; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.; Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Osaka, Japan., Matsuura T; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Kaku N; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Ohfuji S; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Kase T; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Kondo K; OMU Core Facilities Life Sciences Section, Osaka Metropolitan University, Osaka, Japan., Nakagama Y; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Nakagama S; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Nitahara Y; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Takahama S; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan., Kakeya H; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Infection Control Science, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan., Appay V; ImmunoConcEpT, University of Bordeaux, Bordeaux, France., Fukushima W; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan., Kido Y; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan., Yamamoto T; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.; Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Osaka, Japan.; Department of Virology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2026 Jun 07; Vol. 215 (6).
Publication Type: Journal Article
Journal Info: Publisher: American Association of Immunologists Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
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  Data: Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation.
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  Data: <searchLink fieldCode="AU" term="%22Nogimori+T%22">Nogimori T</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Okina+Y%22">Okina Y</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Masuta+Y%22">Masuta Y</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kumamoto+M%22">Kumamoto M</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.; Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuura+T%22">Matsuura T</searchLink>; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kaku+N%22">Kaku N</searchLink>; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohfuji+S%22">Ohfuji S</searchLink>; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kase+T%22">Kase T</searchLink>; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kondo+K%22">Kondo K</searchLink>; OMU Core Facilities Life Sciences Section, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagama+Y%22">Nakagama Y</searchLink>; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagama+S%22">Nakagama S</searchLink>; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nitahara+Y%22">Nitahara Y</searchLink>; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takahama+S%22">Takahama S</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kakeya+H%22">Kakeya H</searchLink>; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Infection Control Science, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Appay+V%22">Appay V</searchLink>; ImmunoConcEpT, University of Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Fukushima+W%22">Fukushima W</searchLink>; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kido+Y%22">Kido Y</searchLink>; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+T%22">Yamamoto T</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan.; Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Osaka, Japan.; Department of Virology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
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