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Model-informed approaches to develop drug cost-saving dosing strategies for pembrolizumab.

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Title: Model-informed approaches to develop drug cost-saving dosing strategies for pembrolizumab.
Authors: Wang Y; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands., Bukkems LH; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands., van Hasselt JGC; Leiden Academic of Drug research, Leiden, the Netherlands., Crombag MR; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the Netherlands., Dumoulin D; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Hendrikx JJMA; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, the Netherlands., Theelen W; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands., van der Hulle T; Department of Medical Oncology, Leiden University Medical Center, the Netherlands., Kapiteijn E; Department of Medical Oncology, Leiden University Medical Center, the Netherlands., Zwaveling J; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands., Becker A; Department of Pulmonology, Amsterdam University Medical Center, the Netherlands., Hiltermann J; Department of Pulmonology, University of Groningen, University Medical Center Groningen, the Netherlands., Hendriks LEL; Department of Pulmonary Diseases, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, the Netherlands., van Geel RMJM; Department of Clinical Pharmacy & Toxicology, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands., van Geffen WH; Department of Pulmonology, Radboudumc, Nijmegen, the Netherlands., van den Heuvel M; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., Oude Munnink TH; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, the Netherlands., Smit EF; Department of Pulmonology, Leiden University Medical Center, the Netherlands., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands., Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands. Electronic address: d.j.a.r.moes@lumc.nl., Ter Heine R; Department of Pharmacy, Pharmacology and Toxicology, Radboudumc, Nijmegen, the Netherlands.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 May 23; Vol. 243, pp. 116829. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bukkems+LH%22">Bukkems LH</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hasselt+JGC%22">van Hasselt JGC</searchLink>; Leiden Academic of Drug research, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Crombag+MR%22">Crombag MR</searchLink>; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dumoulin+D%22">Dumoulin D</searchLink>; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hendrikx+JJMA%22">Hendrikx JJMA</searchLink>; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Theelen+W%22">Theelen W</searchLink>; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Hulle+T%22">van der Hulle T</searchLink>; Department of Medical Oncology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kapiteijn+E%22">Kapiteijn E</searchLink>; Department of Medical Oncology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zwaveling+J%22">Zwaveling J</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Becker+A%22">Becker A</searchLink>; Department of Pulmonology, Amsterdam University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hiltermann+J%22">Hiltermann J</searchLink>; Department of Pulmonology, University of Groningen, University Medical Center Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hendriks+LEL%22">Hendriks LEL</searchLink>; Department of Pulmonary Diseases, GROW - Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Geel+RMJM%22">van Geel RMJM</searchLink>; Department of Clinical Pharmacy & Toxicology, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Geffen+WH%22">van Geffen WH</searchLink>; Department of Pulmonology, Radboudumc, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Heuvel+M%22">van den Heuvel M</searchLink>; Department of Pulmonology, University Medical Center Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Oude+Munnink+TH%22">Oude Munnink TH</searchLink>; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Smit+EF%22">Smit EF</searchLink>; Department of Pulmonology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Guchelaar+HJ%22">Guchelaar HJ</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Moes+DJAR%22">Moes DJAR</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, the Netherlands. Electronic address: d.j.a.r.moes@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Ter+Heine+R%22">Ter Heine R</searchLink>; Department of Pharmacy, Pharmacology and Toxicology, Radboudumc, Nijmegen, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 May 23; Vol. 243, pp. 116829. <i>Date of Electronic Publication: </i>2026 May 23.
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