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Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom.

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Title: Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom.
Authors: Luo G; Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital,Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518020, China.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, 02138, MA, USA., Ma F; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China., Yang Y; Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital,Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518020, China.; Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China., Yang C; The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China., Li X; School of Medicine and Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Shenzhen, 518172, China., Xie J; The State Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head and Neck Surgery, Laboratory of ENT-HNS Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China., Xiong K; Department of Dermatology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Chen P; The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China., Ma K; Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases, School of Medicine, Shihezi University, Shihezi, 832003, China. maketao@shzu.edu.cn., Zhao Z; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China. zhaozheng@cuhk.edu.cn., Tang BZ; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China. tangbenz@cuhk.edu.cn., Duo Y; Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital,Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518020, China. duoduo7753@126.com.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, 02138, MA, USA. duoduo7753@126.com.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 08; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineering an AIEgen-based platform integrating CRISPR/Cas9 to remodel the tumor microenvironment and reinforce photo-immunotherapy against glioblastom.
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  Data: <searchLink fieldCode="AU" term="%22Luo+G%22">Luo G</searchLink>; Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital,Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518020, China.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, 02138, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+F%22">Ma F</searchLink>; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital,Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518020, China.; Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; School of Medicine and Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, Shenzhen, 518172, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; The State Key Laboratory of Respiratory Disease, Department of Otolaryngology, Head and Neck Surgery, Laboratory of ENT-HNS Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.<br /><searchLink fieldCode="AU" term="%22Xiong+K%22">Xiong K</searchLink>; Department of Dermatology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Ma+K%22">Ma K</searchLink>; Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases, School of Medicine, Shihezi University, Shihezi, 832003, China. maketao@shzu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China. zhaozheng@cuhk.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+BZ%22">Tang BZ</searchLink>; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, China. tangbenz@cuhk.edu.cn.<br /><searchLink fieldCode="AU" term="%22Duo+Y%22">Duo Y</searchLink>; Department of Radiation Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital,Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518020, China. duoduo7753@126.com.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, 02138, MA, USA. duoduo7753@126.com.
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              Text: 2026 Jun 08
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