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GPNMB-ECD drives acquired resistance to osimertinib in NSCLC via inducing tumor cell cytoskeletal reorganization.

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Title: GPNMB-ECD drives acquired resistance to osimertinib in NSCLC via inducing tumor cell cytoskeletal reorganization.
Authors: Zhang M; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Wang JQ; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Yang X; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Liu WY; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Huang YT; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Wen CJ; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China., Chen D; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. danchen@cqmu.edu.cn., Wu LX; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. lxwu@cqmu.edu.cn.; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China. lxwu@cqmu.edu.cn.
Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2026 Jun 08. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GPNMB-ECD drives acquired resistance to osimertinib in NSCLC via inducing tumor cell cytoskeletal reorganization.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Wang+JQ%22">Wang JQ</searchLink>; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+WY%22">Liu WY</searchLink>; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Huang+YT%22">Huang YT</searchLink>; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Wen+CJ%22">Wen CJ</searchLink>; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. danchen@cqmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+LX%22">Wu LX</searchLink>; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. lxwu@cqmu.edu.cn.; Pharmacogenetics and Pharmacogenomics Laboratory, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, China. lxwu@cqmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229607427%22">Cellular & molecular biology letters</searchLink> [Cell Mol Biol Lett] 2026 Jun 08. <i>Date of Electronic Publication: </i>2026 Jun 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607427 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1689-1392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214258153%22">14258153 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Biol Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s11658-026-00965-1
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        Text: English
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      – TitleFull: GPNMB-ECD drives acquired resistance to osimertinib in NSCLC via inducing tumor cell cytoskeletal reorganization.
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            – D: 08
              M: 06
              Text: 2026 Jun 08
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              Y: 2026
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