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Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling.

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Title: Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling.
Authors: Gaona IP; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., McCall AS; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Geis NM; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Colvard AC; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., DiGiovanni GT; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Sherrill TP; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Singha UK; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Nichols DS; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Serezani AP; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., David HE; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Cartailler JP; Creative Data Solutions, Center for Stem Cell Biology, Vanderbilt University, Nashville, United States of America., Shrestha S; Creative Data Solutions, Center for Stem Cell Biology, Vanderbilt University, Nashville, United States of America., Gutor SS; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America., Blackwell TS; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America., Kropski JA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America., Gokey JJ; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.
Source: JCI insight [JCI Insight] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling.
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  Data: <searchLink fieldCode="AU" term="%22Gaona+IP%22">Gaona IP</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22McCall+AS%22">McCall AS</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Geis+NM%22">Geis NM</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Colvard+AC%22">Colvard AC</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22DiGiovanni+GT%22">DiGiovanni GT</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Sherrill+TP%22">Sherrill TP</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Singha+UK%22">Singha UK</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Nichols+DS%22">Nichols DS</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Serezani+AP%22">Serezani AP</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22David+HE%22">David HE</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Cartailler+JP%22">Cartailler JP</searchLink>; Creative Data Solutions, Center for Stem Cell Biology, Vanderbilt University, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Shrestha+S%22">Shrestha S</searchLink>; Creative Data Solutions, Center for Stem Cell Biology, Vanderbilt University, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Gutor+SS%22">Gutor SS</searchLink>; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America.<br /><searchLink fieldCode="AU" term="%22Blackwell+TS%22">Blackwell TS</searchLink>; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States of America.<br /><searchLink fieldCode="AU" term="%22Kropski+JA%22">Kropski JA</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.<br /><searchLink fieldCode="AU" term="%22Gokey+JJ%22">Gokey JJ</searchLink>; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of M, Vanderbilt University Medical Center, Nashville, United States of America.
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        Value: 10.1172/jci.insight.198113
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        Text: English
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      – TitleFull: Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling.
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              M: 06
              Text: 2026 Jun 09
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              Y: 2026
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