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Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.

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Title: Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.
Authors: Arunachalam P; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. p.arunachalam@amsterdamumc.nl.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands. p.arunachalam@amsterdamumc.nl., Pieperhoff L; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands., Lorenzini L; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy., Tranfa M; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy., Masserini F; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.; Department of Biomedical and Clinical Sciences, Neuroscience Research Center, University of Milan, Milan, Italy., Treves F; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy., Pontillo G; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.; UCL Queen Square Institute of Neurology, University College London, London, UK., Preti MG; Neuro-X Institute, Ecole Polytechnique Fédérale De Lausanne (EPFL), Geneva, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland., Broeders TAA; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Schoonheim MM; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Douw L; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Ritchie C; Scottish Brain Sciences, Edinburgh, Scotland., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Visser PJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Psychiatry, Maastricht University, Maastricht, the Netherlands., Cacciaglia R; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Gispert JD; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain., Salvadó G; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Luckett ES; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.; Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.; Laboratory for Complex Genetics, KU Leuven, Leuven, Belgium., Collij LE; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands., Cole JH; Hawkes Institute, Department of Computer Science, UCL, London, UK.; Dementia Research Centre, Queen Square Institute of Neurology, UCL, London, UK., Barkhof F; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; UCL Queen Square Institute of Neurology, University College London, London, UK.; Hawkes Institute, Department of Computer Science, UCL, London, UK.; Dementia Research Centre, Queen Square Institute of Neurology, UCL, London, UK., Wink AM; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.
Corporate Authors: AMYPAD consortium
Source: Communications medicine [Commun Med (Lond)] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond)
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Arunachalam+P%22">Arunachalam P</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. p.arunachalam@amsterdamumc.nl.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands. p.arunachalam@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Pieperhoff+L%22">Pieperhoff L</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lorenzini+L%22">Lorenzini L</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Tranfa+M%22">Tranfa M</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Masserini+F%22">Masserini F</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.; Department of Biomedical and Clinical Sciences, Neuroscience Research Center, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Treves+F%22">Treves F</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Pontillo+G%22">Pontillo G</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.; UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Preti+MG%22">Preti MG</searchLink>; Neuro-X Institute, Ecole Polytechnique Fédérale De Lausanne (EPFL), Geneva, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Broeders+TAA%22">Broeders TAA</searchLink>; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schoonheim+MM%22">Schoonheim MM</searchLink>; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Douw+L%22">Douw L</searchLink>; Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ritchie+C%22">Ritchie C</searchLink>; Scottish Brain Sciences, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marquié+M%22">Marquié M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Visser+PJ%22">Visser PJ</searchLink>; 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Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Luckett+ES%22">Luckett ES</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.; Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.; Laboratory for Complex Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Collij+LE%22">Collij LE</searchLink>; Department of Radiology and Nuclear Medicine, UMC Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cole+JH%22">Cole JH</searchLink>; Hawkes Institute, Department of Computer Science, UCL, London, UK.; Dementia Research Centre, Queen Square Institute of Neurology, UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Barkhof+F%22">Barkhof F</searchLink>; 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