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Explainable machine learning-based mortality risk stratification for older adults with COVID-19: pinpointing core immunological biomarkers and revealing dose-threshold effects.

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Title: Explainable machine learning-based mortality risk stratification for older adults with COVID-19: pinpointing core immunological biomarkers and revealing dose-threshold effects.
Authors: Luo L; Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China., Wang L; School of Statistics, Dongbei University of Finance and Economics, Dalian, Liaoning, China., Wang H; School of Statistics, Dongbei University of Finance and Economics, Dalian, Liaoning, China., Li H; School of Statistics, Dongbei University of Finance and Economics, Dalian, Liaoning, China., Liu T; Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China., Yu S; Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Source: Frontiers in immunology [Front Immunol] 2026 May 25; Vol. 17, pp. 1789048. Date of Electronic Publication: 2026 May 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Luo+L%22">Luo L</searchLink>; Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; School of Statistics, Dongbei University of Finance and Economics, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; School of Statistics, Dongbei University of Finance and Economics, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; School of Statistics, Dongbei University of Finance and Economics, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Yu+S%22">Yu S</searchLink>; Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2026.1789048
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