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Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis.

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Title: Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis.
Authors: Xu J; Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China., Zhang J; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Department of Bioinformatics; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China., Li Y; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China., Wang Z; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China., Li Q; Department of Pathology, The Seventh Medical Center of PLA General Hospital, Beijing, China., Liu A; Department of Pathology, The Seventh Medical Center of PLA General Hospital, Beijing, China., Sheng J; Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China., Dong G; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China., Yang L; Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China., Cai Z; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Department of Bioinformatics; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.; Department of Rheumatology and Immunology, Tianjin Medical University Tianjin General Hospital, Tianjin, China.; Department of Hematology, Tianjin Medical University Tianjin General Hospital, Tianjin, China.
Source: Frontiers in immunology [Front Immunol] 2026 May 25; Vol. 17, pp. 1722806. Date of Electronic Publication: 2026 May 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis.
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  Data: <searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Department of Bioinformatics; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Pathology, The Seventh Medical Center of PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+A%22">Liu A</searchLink>; Department of Pathology, The Seventh Medical Center of PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Sheng+J%22">Sheng J</searchLink>; Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Dong+G%22">Dong G</searchLink>; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+Z%22">Cai Z</searchLink>; State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, China.; Department of Bioinformatics; The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Inflammatory Biology; Department of Pharmacology, School of Basic Medical Science, Tianjin Medical University, Tianjin, China.; Department of Rheumatology and Immunology, Tianjin Medical University Tianjin General Hospital, Tianjin, China.; Department of Hematology, Tianjin Medical University Tianjin General Hospital, Tianjin, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 May 25; Vol. 17, pp. 1722806. <i>Date of Electronic Publication: </i>2026 May 25 (<i>Print Publication: </i>2026).
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              Text: 2026 May 25
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