Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function.
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| Title: | Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function. |
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| Authors: | Nakhe AY; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dobson JR; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Westover D; High-Throughput Analytics, Analytical Research and Development, Merck & Co. Inc., Rahway, New Jersey., Days EL; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee., Vinson P; High-Throughput Screening Center, Southern Research, Birmingham, Alabama., Weaver CD; Department of Chemistry, Department of Pharmacology, and Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee., Denton JS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee., Peachee SJ; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Behera S; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Gibson SE; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Rodriguez Da Silva VA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Sela A; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee., Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee. Electronic address: david.a.jacobson@vanderbilt.edu. |
| Source: | Molecular pharmacology [Mol Pharmacol] 2026 May-Jun; Vol. 108 (5-6), pp. 100130. Date of Electronic Publication: 2026 May 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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