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PRMT5-mediated methylation of LKB1 controls PD-L1 expression in NSCLC.

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Title: PRMT5-mediated methylation of LKB1 controls PD-L1 expression in NSCLC.
Authors: Shen YC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan., Nguyen KTL; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; CIRTECH Institute, HUTECH University, Ho Chi Minh City, Vietnam., Wang BW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan., Cheng FJ; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Kyoto, Japan., Chen BR; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Kyoto, Japan., Hu SW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan., Chen PY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan., Hsu JM; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan., Wei YL; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan., Huang WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; School of Pharmacy, China Medical University, Taichung, Taiwan; Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address: whuang@mail.cmu.edu.tw., Tu CY; School of Medicine, China Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: chesttu@gmail.com., Chen CH; School of Medicine, China Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: hsnu758@gmail.com.
Source: Biomedical journal [Biomed J] 2026 Jun 10, pp. 101002. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101599820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2320-2890 (Electronic) Linking ISSN: 23194170 NLM ISO Abbreviation: Biomed J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PRMT5-mediated methylation of LKB1 controls PD-L1 expression in NSCLC.
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  Data: <searchLink fieldCode="AU" term="%22Shen+YC%22">Shen YC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+KTL%22">Nguyen KTL</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; CIRTECH Institute, HUTECH University, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Wang+BW%22">Wang BW</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+FJ%22">Cheng FJ</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+BR%22">Chen BR</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hu+SW%22">Hu SW</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PY%22">Chen PY</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+JM%22">Hsu JM</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wei+YL%22">Wei YL</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+WC%22">Huang WC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan; School of Pharmacy, China Medical University, Taichung, Taiwan; Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address: whuang@mail.cmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Tu+CY%22">Tu CY</searchLink>; School of Medicine, China Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: chesttu@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; School of Medicine, China Medical University, Taichung, Taiwan; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: hsnu758@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101599820%22">Biomedical journal</searchLink> [Biomed J] 2026 Jun 10, pp. 101002. <i>Date of Electronic Publication: </i>2026 Jun 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101599820 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2320-2890 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223194170%22">23194170 </searchLink><i>NLM ISO Abbreviation: </i>Biomed J <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.bj.2026.101002
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        Text: English
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        StartPage: 101002
    Titles:
      – TitleFull: PRMT5-mediated methylation of LKB1 controls PD-L1 expression in NSCLC.
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            – D: 10
              M: 06
              Text: 2026 Jun 10
              Type: published
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