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Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics.

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Title: Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics.
Authors: Tang X; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China., Shi Y; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China., Pan J; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China., Zhao Y; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China., Huang M; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China., Su H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, China.; Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Zhou W; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Luo X; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China., Luo X; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Zhang J; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Zhao J; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Jia J; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Li J; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Zhong B; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China., Tang L; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China., Chen Z; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China., Ouyang Y; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Dang Z; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., French SW; Department of Pathology, Harbor UCLA Medical Center, University of California, Torrance, CA, USA., Huang Y; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. hyh930@sina.com.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China. hyh930@sina.com., Pan X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, China. panxinghua@must.edu.mo.; Precision Regenerative Medicine Research Centre, Medical Science Division, Macau University of Science and Technology, Macao, China. panxinghua@must.edu.mo., Liu H; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. liuhui806@gzhmu.edu.cn.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China. liuhui806@gzhmu.edu.cn.; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China. liuhui806@gzhmu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 11; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unraveling the HGF/MET axis in Mallory-Denk body pathogenesis associated with liver fibrosis through single-cell transcriptomics.
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  Data: <searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China.<br /><searchLink fieldCode="AU" term="%22Su+H%22">Su H</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, China.; 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The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+Y%22">Ouyang Y</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Dang+Z%22">Dang Z</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22French+SW%22">French SW</searchLink>; Department of Pathology, Harbor UCLA Medical Center, University of California, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. hyh930@sina.com.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China. hyh930@sina.com.<br /><searchLink fieldCode="AU" term="%22Pan+X%22">Pan X</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, China. panxinghua@must.edu.mo.; Precision Regenerative Medicine Research Centre, Medical Science Division, Macau University of Science and Technology, Macao, China. panxinghua@must.edu.mo.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Clinical Laboratory, the Fifth Affiliated Hospital of Guangzhou Medical University, Center for Liver Diseases of Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. liuhui806@gzhmu.edu.cn.; The State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou Medical University, Guangzhou, China. liuhui806@gzhmu.edu.cn.; The Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's hospital, Qingyuan, China. liuhui806@gzhmu.edu.cn.
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              Text: 2026 Jun 11
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