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PHGDH loss promotes hypoxia tolerance through glycolytic reprogramming and enhanced HIF-1 activity.

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Title: PHGDH loss promotes hypoxia tolerance through glycolytic reprogramming and enhanced HIF-1 activity.
Authors: Petrosyan E; Department of Oncology, The University of Oxford, Oxford, UK., Martin LAW; Department of Oncology, The University of Oxford, Oxford, UK., Legge I; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Walsby-Tickle J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Sedgwick AC; Department of Chemistry, King's College London, London, UK., Hill MA; Department of Oncology, The University of Oxford, Oxford, UK., McCullagh JSO; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Olcina MM; Department of Oncology, The University of Oxford, Oxford, UK., Hammond EM; Department of Oncology, The University of Oxford, Oxford, UK. ester.hammond@oncology.ox.ac.uk.
Source: Cell death discovery [Cell Death Discov] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Petrosyan+E%22">Petrosyan E</searchLink>; Department of Oncology, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Martin+LAW%22">Martin LAW</searchLink>; Department of Oncology, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Legge+I%22">Legge I</searchLink>; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Walsby-Tickle+J%22">Walsby-Tickle J</searchLink>; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sedgwick+AC%22">Sedgwick AC</searchLink>; Department of Chemistry, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hill+MA%22">Hill MA</searchLink>; Department of Oncology, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McCullagh+JSO%22">McCullagh JSO</searchLink>; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Olcina+MM%22">Olcina MM</searchLink>; Department of Oncology, The University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hammond+EM%22">Hammond EM</searchLink>; Department of Oncology, The University of Oxford, Oxford, UK. ester.hammond@oncology.ox.ac.uk.
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        Value: 10.1038/s41420-026-03194-9
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              Text: 2026 Jun 10
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