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CDK10 loss primes tumor cells for transcriptional vulnerability and sensitizes to CDK12/13 inhibition.

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Title: CDK10 loss primes tumor cells for transcriptional vulnerability and sensitizes to CDK12/13 inhibition.
Authors: Islam S; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan., Tarumoto Y; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Takano M; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Sugino S; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Nishibuchi G; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Mizutani A; Chordia Therapeutics, Inc, Kanagawa, Japan., Yamakawa H; Chordia Therapeutics, Inc, Kanagawa, Japan., Morishita D; Chordia Therapeutics, Inc, Kanagawa, Japan., Yusa K; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. k.yusa@infront.kyoto-u.ac.jp.
Source: Cell death & disease [Cell Death Dis] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: CDK10 loss primes tumor cells for transcriptional vulnerability and sensitizes to CDK12/13 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Islam+S%22">Islam S</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tarumoto+Y%22">Tarumoto Y</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Takano+M%22">Takano M</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sugino+S%22">Sugino S</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nishibuchi+G%22">Nishibuchi G</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Mizutani+A%22">Mizutani A</searchLink>; Chordia Therapeutics, Inc, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Yamakawa+H%22">Yamakawa H</searchLink>; Chordia Therapeutics, Inc, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Morishita+D%22">Morishita D</searchLink>; Chordia Therapeutics, Inc, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Yusa+K%22">Yusa K</searchLink>; Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. k.yusa@infront.kyoto-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Jun 11. <i>Date of Electronic Publication: </i>2026 Jun 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41419-026-08973-x
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              Text: 2026 Jun 11
              Type: published
              Y: 2026
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