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Cerebrovascular vulnerability and fibrosis in human brain aneurysms.

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Title: Cerebrovascular vulnerability and fibrosis in human brain aneurysms.
Authors: Wang JC; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Kim CN; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA., Bhalla S; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Scherschinski L; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA., Gopinadhan A; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Arul S; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Sanchez D; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Schriber TD; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA., Apolonio ACM; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Gülsuyu B; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Öztürk MM; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Andrews JP; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Kim J; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Jahromi BR; Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Niemelä M; Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Lehecka M; Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Poddar A; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Wälchli T; Brain Vasculature and Perivascular Niche Laboratory, Department of Oncology, University College London Cancer Institute, University College London, London, UK.; Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, Queen Square, London, UK., Catapano JS; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA., Sen RD; Departments of Neurological Surgery, Radiology, Neurology, Mechanical Engineering, and Stroke & Applied Neuroscience Center, University of Washington, Seattle, WA, USA., Levitt MR; Departments of Neurological Surgery, Radiology, Neurology, Mechanical Engineering, and Stroke & Applied Neuroscience Center, University of Washington, Seattle, WA, USA., Cooke DL; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA., Narsinh K; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA., Jha RM; Department of Neurology, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA., Hashimoto T; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA., Oh SP; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA., Huang EJ; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA., Chang EF; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Lim DA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA., Abla AA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA., Yang AC; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Nowakowski TJ; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA., Lawton MT; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA. michael.lawton@barrowbrainandspine.com.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA. michael.lawton@barrowbrainandspine.com., Winkler EA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. ethan.winkler@ucsf.edu.
Source: Nature neuroscience [Nat Neurosci] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+JC%22">Wang JC</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+CN%22">Kim CN</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhalla+S%22">Bhalla S</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Scherschinski+L%22">Scherschinski L</searchLink>; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; 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Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lehecka+M%22">Lehecka M</searchLink>; Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Poddar+A%22">Poddar A</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wälchli+T%22">Wälchli T</searchLink>; Brain Vasculature and Perivascular Niche Laboratory, Department of Oncology, University College London Cancer Institute, University College London, London, UK.; Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, Queen Square, London, UK.<br /><searchLink fieldCode="AU" term="%22Catapano+JS%22">Catapano JS</searchLink>; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; 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Department of Neurology, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Hashimoto+T%22">Hashimoto T</searchLink>; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Oh+SP%22">Oh SP</searchLink>; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Huang+EJ%22">Huang EJ</searchLink>; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+EF%22">Chang EF</searchLink>; 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Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lawton+MT%22">Lawton MT</searchLink>; Department of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA. michael.lawton@barrowbrainandspine.com.; Barrow Aneurysm and AVM Research Center, Department of Translational Neuroscience, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ, USA. michael.lawton@barrowbrainandspine.com.<br /><searchLink fieldCode="AU" term="%22Winkler+EA%22">Winkler EA</searchLink>; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. ethan.winkler@ucsf.edu.
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