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Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.

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Title: Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
Authors: Heersche N; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.; 2Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands., Peeters SLJ; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Böhm D; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Böhringer S; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.; 5Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Guiljam R; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Hulshof EC; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., de Man FM; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., de With M; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.; 2Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands., Joosse M; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands., Oomens G; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands., Wu QY; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Bins S; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., van Hellemond IEG; 6Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Haberkorn BCM; 7Department of Medical Oncology, Maasstad Hospital, Rotterdam, the Netherlands., Verschoor AJ; 8Department of Medical Oncology, Reinier de Graaf Gasthuis, Delft, the Netherlands., Wumkes ML; 9Department of Medical Oncology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands., Thijs AM; 6Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., van Schaik RHN; 2Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands., Gelderblom H; 10Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Guchelaar HJ; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands., Mathijssen RHJ; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands., Deenen MJ; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.
Source: Journal of the National Comprehensive Cancer Network : JNCCN [J Natl Compr Canc Netw] 2026 Jun 11, pp. 1-8. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Harborside Press Country of Publication: United States NLM ID: 101162515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-1413 (Electronic) Linking ISSN: 15401405 NLM ISO Abbreviation: J Natl Compr Canc Netw Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Heersche+N%22">Heersche N</searchLink>; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.; 2Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peeters+SLJ%22">Peeters SLJ</searchLink>; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Böhm+D%22">Böhm D</searchLink>; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Böhringer+S%22">Böhringer S</searchLink>; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.; 5Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Guiljam+R%22">Guiljam R</searchLink>; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hulshof+EC%22">Hulshof EC</searchLink>; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Man+FM%22">de Man FM</searchLink>; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+With+M%22">de With M</searchLink>; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.; 2Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Joosse+M%22">Joosse M</searchLink>; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Oomens+G%22">Oomens G</searchLink>; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wu+QY%22">Wu QY</searchLink>; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bins+S%22">Bins S</searchLink>; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hellemond+IEG%22">van Hellemond IEG</searchLink>; 6Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Haberkorn+BCM%22">Haberkorn BCM</searchLink>; 7Department of Medical Oncology, Maasstad Hospital, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verschoor+AJ%22">Verschoor AJ</searchLink>; 8Department of Medical Oncology, Reinier de Graaf Gasthuis, Delft, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wumkes+ML%22">Wumkes ML</searchLink>; 9Department of Medical Oncology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Thijs+AM%22">Thijs AM</searchLink>; 6Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Schaik+RHN%22">van Schaik RHN</searchLink>; 2Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gelderblom+H%22">Gelderblom H</searchLink>; 10Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Guchelaar+HJ%22">Guchelaar HJ</searchLink>; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mathijssen+RHJ%22">Mathijssen RHJ</searchLink>; 1Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Deenen+MJ%22">Deenen MJ</searchLink>; 3Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; 4Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.
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