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Expression of progranulin (GP88) protein appears as an independent prognostic factor for clinical progression in high-risk prostate cancer patients.

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Title: Expression of progranulin (GP88) protein appears as an independent prognostic factor for clinical progression in high-risk prostate cancer patients.
Authors: Dubrovska R; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany., Eckstein M; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Jung R; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Kalogirou C; Department of Urology and Paediatric Urology, University Hospital Würzburg, 97080, Würzburg, Germany., Kneitz B; Department of Urology and Paediatric Urology, University Hospital Würzburg, 97080, Würzburg, Germany., Spahn M; Lindenhofspital, Bern, Switzerland., Kruithof-de Julio M; Department of Urology, Inselspital, Bern University Hospital, Bern, Switzerland., Serrero G; A&G Pharmaceutical Inc., Columbia, MD, 21045, USA.; Program in Oncology, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, 21201, USA., Yue B; Program in Oncology, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, 21201, USA., Geppert C; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Stöhr R; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Hartmann A; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Wullich B; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Lieb V; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Taubert H; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany., Wach S; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. sven.wach@uk-erlangen.de.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany. sven.wach@uk-erlangen.de.
Source: Scientific reports [Sci Rep] 2026 Jun 11; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Expression of progranulin (GP88) protein appears as an independent prognostic factor for clinical progression in high-risk prostate cancer patients.
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  Data: <searchLink fieldCode="AU" term="%22Dubrovska+R%22">Dubrovska R</searchLink>; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Eckstein+M%22">Eckstein M</searchLink>; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+R%22">Jung R</searchLink>; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kalogirou+C%22">Kalogirou C</searchLink>; Department of Urology and Paediatric Urology, University Hospital Würzburg, 97080, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kneitz+B%22">Kneitz B</searchLink>; Department of Urology and Paediatric Urology, University Hospital Würzburg, 97080, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Spahn+M%22">Spahn M</searchLink>; Lindenhofspital, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kruithof-de+Julio+M%22">Kruithof-de Julio M</searchLink>; Department of Urology, Inselspital, Bern University Hospital, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Serrero+G%22">Serrero G</searchLink>; A&G Pharmaceutical Inc., Columbia, MD, 21045, USA.; Program in Oncology, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Yue+B%22">Yue B</searchLink>; Program in Oncology, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Geppert+C%22">Geppert C</searchLink>; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Stöhr+R%22">Stöhr R</searchLink>; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+A%22">Hartmann A</searchLink>; Department of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wullich+B%22">Wullich B</searchLink>; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Lieb+V%22">Lieb V</searchLink>; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Taubert+H%22">Taubert H</searchLink>; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wach+S%22">Wach S</searchLink>; Department of Urology and Pediatric Urology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany. sven.wach@uk-erlangen.de.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), 91054, Erlangen, Germany. sven.wach@uk-erlangen.de.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Jun 11; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Jun 11.
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