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Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response.

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Title: Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response.
Authors: Moore AR; Department of Research Oncology, Genentech, South San Francisco, CA, USA.; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Biehs B; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Kljavin N; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Nguyen TTT; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA., Shah A; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Burton J; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Jiang H; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Tan J; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Chakroborty D; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Wang L; Department of Real World Data Science, Genentech, South San Francisco, CA, USA., Chaudhary N; Department of Real World Data Science, Genentech, South San Francisco, CA, USA., He D; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA., Lin W; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Mesh K; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Ye X; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Bhat KP; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Tai L; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Xie S; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Ye W; Department of Research Oncology, Genentech, South San Francisco, CA, USA., McGinnis L; Department of Research Pathology, Genentech, South San Francisco, CA, USA.; Department of Cellular and Tissue Genomics, Genentech, South San Francisco, CA, USA., Malek S; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Melo SP; Department of Research Oncology, Genentech, South San Francisco, CA, USA. melo-carlos.sandra@gene.com.; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA. melo-carlos.sandra@gene.com., de Sauvage FJ; Department of Research Oncology, Genentech, South San Francisco, CA, USA. desauvage.fred@gene.com.
Source: Nature genetics [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1331-1340. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response.
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  Data: <searchLink fieldCode="AU" term="%22Moore+AR%22">Moore AR</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Biehs+B%22">Biehs B</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kljavin+N%22">Kljavin N</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TTT%22">Nguyen TTT</searchLink>; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shah+A%22">Shah A</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Burton+J%22">Burton J</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chakroborty+D%22">Chakroborty D</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Real World Data Science, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhary+N%22">Chaudhary N</searchLink>; Department of Real World Data Science, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22He+D%22">He D</searchLink>; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+W%22">Lin W</searchLink>; Department of Research Pathology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mesh+K%22">Mesh K</searchLink>; Department of Research Pathology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ye+X%22">Ye X</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhat+KP%22">Bhat KP</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tai+L%22">Tai L</searchLink>; Department of Research Pathology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xie+S%22">Xie S</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22McGinnis+L%22">McGinnis L</searchLink>; Department of Research Pathology, Genentech, South San Francisco, CA, USA.; Department of Cellular and Tissue Genomics, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Malek+S%22">Malek S</searchLink>; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melo+SP%22">Melo SP</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA. melo-carlos.sandra@gene.com.; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA. melo-carlos.sandra@gene.com.<br /><searchLink fieldCode="AU" term="%22de+Sauvage+FJ%22">de Sauvage FJ</searchLink>; Department of Research Oncology, Genentech, South San Francisco, CA, USA. desauvage.fred@gene.com.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1331-1340. <i>Date of Electronic Publication: </i>2026 Jun 11.
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