Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response.
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| Title: | Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response. |
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| Authors: | Moore AR; Department of Research Oncology, Genentech, South San Francisco, CA, USA.; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Biehs B; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Kljavin N; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Nguyen TTT; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA., Shah A; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Burton J; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Jiang H; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Tan J; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Chakroborty D; Department of Research Oncology, Genentech, South San Francisco, CA, USA., Wang L; Department of Real World Data Science, Genentech, South San Francisco, CA, USA., Chaudhary N; Department of Real World Data Science, Genentech, South San Francisco, CA, USA., He D; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA., Lin W; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Mesh K; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Ye X; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Bhat KP; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Tai L; Department of Research Pathology, Genentech, South San Francisco, CA, USA., Xie S; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Ye W; Department of Research Oncology, Genentech, South San Francisco, CA, USA., McGinnis L; Department of Research Pathology, Genentech, South San Francisco, CA, USA.; Department of Cellular and Tissue Genomics, Genentech, South San Francisco, CA, USA., Malek S; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Melo SP; Department of Research Oncology, Genentech, South San Francisco, CA, USA. melo-carlos.sandra@gene.com.; Computational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA. melo-carlos.sandra@gene.com., de Sauvage FJ; Department of Research Oncology, Genentech, South San Francisco, CA, USA. desauvage.fred@gene.com. |
| Source: | Nature genetics [Nat Genet] 2026 Jun; Vol. 58 (6), pp. 1331-1340. Date of Electronic Publication: 2026 Jun 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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