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Exercise reduces hepatic pre-metastatic niche formation via TREM-1 signaling in kupffer cells.

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Title: Exercise reduces hepatic pre-metastatic niche formation via TREM-1 signaling in kupffer cells.
Authors: Yang R; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China., Haykal T; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Tohme C; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., He Z; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China., Zhang H; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China., Gebran A; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Liu S; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Simmons RL; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Geller DA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Yazdani HO; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. obaidh3@upmc.edu.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. obaidh3@upmc.edu., Tohme S; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. tohmest@upmc.edu.
Source: BMC medicine [BMC Med] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exercise reduces hepatic pre-metastatic niche formation via TREM-1 signaling in kupffer cells.
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  Data: <searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Haykal+T%22">Haykal T</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tohme+C%22">Tohme C</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gebran+A%22">Gebran A</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+RL%22">Simmons RL</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Geller+DA%22">Geller DA</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yazdani+HO%22">Yazdani HO</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. obaidh3@upmc.edu.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. obaidh3@upmc.edu.<br /><searchLink fieldCode="AU" term="%22Tohme+S%22">Tohme S</searchLink>; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. tohmest@upmc.edu.
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        Value: 10.1186/s12916-026-04885-x
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      – TitleFull: Exercise reduces hepatic pre-metastatic niche formation via TREM-1 signaling in kupffer cells.
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              Text: 2026 Jun 11
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