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Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.

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Title: Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.
Authors: Chai RC; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, NSW, Australia.; These authors contributed equally: Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal & James T. Smith., Lundberg M; Transformational Bioinformatics, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia.; UQ Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.; These authors contributed equally: Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal & James T. Smith., Freudenthal B; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; These authors contributed equally: Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal & James T. Smith., Smith JT; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, NSW, Australia.; These authors contributed equally: Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal & James T. Smith., Boughton AP; Department of Biostatistics and the Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Zhang Y; Mater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia., Flynn KA; Mater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia., Frysz M; University of Bristol, Musculoskeletal Research Unit, Bristol Medical School, Bristol, United Kingdom., Corr AP; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Khoo WH; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Komla-Ebri D; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Dack MRG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Guilfoyle SE; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Logan JG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Butterfield NC; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Leitch VD; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Pollard AS; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Mäkitie RE; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, HUS, Kasarmikatu 11-13, 00029, Helsinki, Finland.; Faculty of Medicine, University of Helsinki, Helsinki, Finland., Bradford N; St. Vincent's Hospital, Darlinghurst, NSW, Australia., Ramos-Mucci L; Relation Therapeutics, London, UK., Vilas-Zornoza A; Relation Therapeutics, London, UK., Chen Y; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Yip RKH; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Er J; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Tan SZ; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia., McDonald MM; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Youlten SE; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA., Sergio CM; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Castro-Martinez A; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Young SG; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Skorokhodova E; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Evans DM; UQ Frazer Institute, The University of Queensland, Woolloongabba, QLD, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Powell JE; Translational Genomics Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; UNSW Cellular Genomics Futures Institute, UNSW Sydney, NSW, Australia., de Leeuw CA; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The Netherlands., Ewing AD; Mater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia., Eisman JA; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, NSW, Australia., Blank RD; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; Division of Endocrinology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Phan TG; School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, NSW, Australia.; Precision Immunology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Lagendijk AK; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.; School of Biomedical Science, The University of Queensland, St Lucia, QLD, Australia.; UQ Centre for Cardiovascular Health and Research (CCVHR), The University of Queensland, St Lucia, QLD, Australia., Hawkins ED; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Oh HL; St. Vincent's Hospital, Darlinghurst, NSW, Australia., McIntyre R; Relation Therapeutics, London, UK., Hessel EM; Relation Therapeutics, London, UK., Taylor-King JP; Relation Therapeutics, London, UK., Baldock PA; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia., Duncan EL; School of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.; Guy's and St Thomas' NHS Foundation Trust, London, UK., Williams GR; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; These authors jointly supervised this work: Graham R. Williams, J. H. Duncan Bassett, Peter I. Croucher & John P. Kemp., Bassett JHD; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; These authors jointly supervised this work: Graham R. Williams, J. H. Duncan Bassett, Peter I. Croucher & John P. Kemp., Croucher PI; Cancer Plasticity and Dormancy Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW, Sydney, NSW, Australia.; These authors jointly supervised this work: Graham R. Williams, J. H. Duncan Bassett, Peter I. Croucher & John P. Kemp., Kemp JP; Mater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.; These authors jointly supervised this work: Graham R. Williams, J. H. Duncan Bassett, Peter I. Croucher & John P. Kemp.
Corporate Authors: International Federation of Musculoskeletal Research Societies (IFMRS) Big Data Working Group
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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      – PersonEntity:
          Name:
            NameFull: Bassett JHD
      – PersonEntity:
          Name:
            NameFull: Croucher PI
      – PersonEntity:
          Name:
            NameFull: Kemp JP
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1