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Helminth infection modulates the immunogenicity of COVID-19 vaccines in mice without compromising protective efficacy.

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Title: Helminth infection modulates the immunogenicity of COVID-19 vaccines in mice without compromising protective efficacy.
Authors: Su J; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Hamway Y; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Mistretta D; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany., Liao BH; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany., Ma Z; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany., Schluckebier J; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Xie Z; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany., Polezhaeva O; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany., Jradi W; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Braun S; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany., Robb J; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Main LF; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany., Mukherjee P; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Jubran-Rudolf L; Comparative Experimental Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Steiger K; Comparative Experimental Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Pino P; School of Medicine and Health, ExcellGene SA, Monthey, Switzerland., Tenbusch M; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., D'Ippolito E; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany., Ebert G; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Protzer U; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Prazeres da Costa C; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 May 28; Vol. 17, pp. 1827532. Date of Electronic Publication: 2026 May 28 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Helminth infection modulates the immunogenicity of COVID-19 vaccines in mice without compromising protective efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hamway+Y%22">Hamway Y</searchLink>; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mistretta+D%22">Mistretta D</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Liao+BH%22">Liao BH</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ma+Z%22">Ma Z</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schluckebier+J%22">Schluckebier J</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Xie+Z%22">Xie Z</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Polezhaeva+O%22">Polezhaeva O</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jradi+W%22">Jradi W</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Braun+S%22">Braun S</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Robb+J%22">Robb J</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Main+LF%22">Main LF</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mukherjee+P%22">Mukherjee P</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jubran-Rudolf+L%22">Jubran-Rudolf L</searchLink>; Comparative Experimental Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Steiger+K%22">Steiger K</searchLink>; Comparative Experimental Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pino+P%22">Pino P</searchLink>; School of Medicine and Health, ExcellGene SA, Monthey, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tenbusch+M%22">Tenbusch M</searchLink>; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22D'Ippolito+E%22">D'Ippolito E</searchLink>; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ebert+G%22">Ebert G</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Protzer+U%22">Protzer U</searchLink>; Institute of Virology, School of Medicine and Health, Technical University of Munich/Helmholtz Munich, Munich, Germany.; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Prazeres+da+Costa+C%22">Prazeres da Costa C</searchLink>; School of Medicine and Health, German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.; Center for Global Health, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
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