CLEC4G Promotes Pancreatic Cancer Progression by Suppressing Cathepsin B-Mediated Ferroptosis: Evidence From Mendelian Randomization Study and Experimental Validation.

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Title: CLEC4G Promotes Pancreatic Cancer Progression by Suppressing Cathepsin B-Mediated Ferroptosis: Evidence From Mendelian Randomization Study and Experimental Validation.
Authors: Jiang Z; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Ma P; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Zhang S; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn., Jin Z; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn., Wang Y; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Zhou Y; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Zhu Q; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Lu C; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Tu N; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn., Zhang ZA; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn., Mou Y; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China., Jin W; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.
Source: Human mutation [Hum Mutat] 2026 Jun 10; Vol. 2026, pp. 7359548. Date of Electronic Publication: 2026 Jun 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9215429 Publication Model: eCollection Cited Medium: Internet ISSN: 1098-1004 (Electronic) Linking ISSN: 10597794 NLM ISO Abbreviation: Hum Mutat Subsets: MEDLINE
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  Data: CLEC4G Promotes Pancreatic Cancer Progression by Suppressing Cathepsin B-Mediated Ferroptosis: Evidence From Mendelian Randomization Study and Experimental Validation.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+Z%22">Jiang Z</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Ma+P%22">Ma P</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.<br /><searchLink fieldCode="AU" term="%22Jin+Z%22">Jin Z</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Q%22">Zhu Q</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Tu+N%22">Tu N</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+ZA%22">Zhang ZA</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Mou+Y%22">Mou Y</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Jin+W%22">Jin W</searchLink>; General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, China.
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  Data: <searchLink fieldCode="JN" term="%229215429%22">Human mutation</searchLink> [Hum Mutat] 2026 Jun 10; Vol. 2026, pp. 7359548. <i>Date of Electronic Publication: </i>2026 Jun 10 (<i>Print Publication: </i>2026).
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        Value: 10.1155/humu/7359548
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      – TitleFull: CLEC4G Promotes Pancreatic Cancer Progression by Suppressing Cathepsin B-Mediated Ferroptosis: Evidence From Mendelian Randomization Study and Experimental Validation.
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