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Therapeutic Drug Monitoring and Model-Informed Precision Dosing of Oral TKIs and PARP Inhibitors: A Practical Framework for Clinical Implementation.

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Title: Therapeutic Drug Monitoring and Model-Informed Precision Dosing of Oral TKIs and PARP Inhibitors: A Practical Framework for Clinical Implementation.
Authors: Torrent-Rodríguez A; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain., Bastida C; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain. cbastida@clinic.cat.; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain. cbastida@clinic.cat., Martín ECS; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain., Escartín IM; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain., Puszkiel A; Department of Pharmacokinetics and Pharmacochemistry, Cochin University Hospital, Paris, France.; Faculty of Pharmacy, Inserm UMR-S1144, Université Paris Cité, Paris, France., Blanchet B; Department of Pharmacokinetics and Pharmacochemistry, Cochin University Hospital, Paris, France., Laguna JC; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain., Gorria T; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain., Montes A; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain., Macías I; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain., Alvárez A; Hematology Department, Hospital Clinic de Barcelona, Barcelona, Spain., Arance A; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain., Moreno FA; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain., Fabregat-Bolufer AB; Biochemistry and Molecular Genetics Department, CDB, Hospital Clínic of Barcelona, Barcelona, Spain., Soler E; New Therapies Unit (IntherUnit), Hospital Clinic de Barcelona, Barcelona, Spain., Muner DS; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article; Review
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Torrent-Rodríguez+A%22">Torrent-Rodríguez A</searchLink>; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bastida+C%22">Bastida C</searchLink>; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain. cbastida@clinic.cat.; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain. cbastida@clinic.cat.<br /><searchLink fieldCode="AU" term="%22Martín+ECS%22">Martín ECS</searchLink>; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Escartín+IM%22">Escartín IM</searchLink>; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Puszkiel+A%22">Puszkiel A</searchLink>; Department of Pharmacokinetics and Pharmacochemistry, Cochin University Hospital, Paris, France.; Faculty of Pharmacy, Inserm UMR-S1144, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Blanchet+B%22">Blanchet B</searchLink>; Department of Pharmacokinetics and Pharmacochemistry, Cochin University Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Laguna+JC%22">Laguna JC</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gorria+T%22">Gorria T</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Montes+A%22">Montes A</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.; Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Macías+I%22">Macías I</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Alvárez+A%22">Alvárez A</searchLink>; Hematology Department, Hospital Clinic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arance+A%22">Arance A</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno+FA%22">Moreno FA</searchLink>; Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fabregat-Bolufer+AB%22">Fabregat-Bolufer AB</searchLink>; Biochemistry and Molecular Genetics Department, CDB, Hospital Clínic of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Soler+E%22">Soler E</searchLink>; New Therapies Unit (IntherUnit), Hospital Clinic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Muner+DS%22">Muner DS</searchLink>; Pharmacy Service, Division of Medicines, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain.; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.
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