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Progression risk among responders to PD-1/PD-L1 blockade is primarily stratified by response depth: A nationwide cohort study of 2127 patients with melanoma, RCC, and NSCLC.

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Title: Progression risk among responders to PD-1/PD-L1 blockade is primarily stratified by response depth: A nationwide cohort study of 2127 patients with melanoma, RCC, and NSCLC.
Authors: Andersen R; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Jespersen MS; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Presti M; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Bjornhart B; Department of Oncology, Odense University Hospital, Odense, Denmark., Østby AC; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Darras AKM; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Garitaonaindia Y; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Ruhlmann CH; Department of Oncology, Odense University Hospital, Odense, Denmark., Frank MS; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Schmidt H; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Friis RB; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Guldbrandt LM; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Henriksen JR; Department of Oncology, Odense University Hospital, Odense, Denmark., Bjerrum A; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Simonsen KS; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Palshof JA; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Borch TH; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Andersen JL; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Kjaer S; Department of Oncology, Odense University Hospital, Odense, Denmark., Jensen NV; Department of Oncology, Odense University Hospital, Odense, Denmark., Azimi A; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Iversen AB; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Meldgaard P; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Steen SG; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Khan S; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Luczak AA; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Wahlstrøm S; Department of Oncology, North Zealand Hospital, Hilleroed, Denmark., Zitnjak D; Department of Oncology, South Jutland Hospital, Soenderborg, Denmark., Svane IM; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Fristrup N; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Kristiansen C; Department of Oncology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark., Persson GF; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Bastholt L; Department of Oncology, Odense University Hospital, Odense, Denmark., Poehl M; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Ellebaek E; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark., Donia M; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: marco.donia@regionh.dk.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 05; Vol. 243, pp. 116872. Date of Electronic Publication: 2026 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Progression risk among responders to PD-1/PD-L1 blockade is primarily stratified by response depth: A nationwide cohort study of 2127 patients with melanoma, RCC, and NSCLC.
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  Data: <searchLink fieldCode="AU" term="%22Andersen+R%22">Andersen R</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Jespersen+MS%22">Jespersen MS</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Presti+M%22">Presti M</searchLink>; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Bjornhart+B%22">Bjornhart B</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Østby+AC%22">Østby AC</searchLink>; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Darras+AKM%22">Darras AKM</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Garitaonaindia+Y%22">Garitaonaindia Y</searchLink>; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Ruhlmann+CH%22">Ruhlmann CH</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Frank+MS%22">Frank MS</searchLink>; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Schmidt+H%22">Schmidt H</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Friis+RB%22">Friis RB</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Guldbrandt+LM%22">Guldbrandt LM</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Henriksen+JR%22">Henriksen JR</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Bjerrum+A%22">Bjerrum A</searchLink>; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Simonsen+KS%22">Simonsen KS</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Palshof+JA%22">Palshof JA</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Borch+TH%22">Borch TH</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+JL%22">Andersen JL</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Kjaer+S%22">Kjaer S</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+NV%22">Jensen NV</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Azimi+A%22">Azimi A</searchLink>; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Iversen+AB%22">Iversen AB</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Meldgaard+P%22">Meldgaard P</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Steen+SG%22">Steen SG</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Khan+S%22">Khan S</searchLink>; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Luczak+AA%22">Luczak AA</searchLink>; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Wahlstrøm+S%22">Wahlstrøm S</searchLink>; Department of Oncology, North Zealand Hospital, Hilleroed, Denmark.<br /><searchLink fieldCode="AU" term="%22Zitnjak+D%22">Zitnjak D</searchLink>; Department of Oncology, South Jutland Hospital, Soenderborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Svane+IM%22">Svane IM</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fristrup+N%22">Fristrup N</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Kristiansen+C%22">Kristiansen C</searchLink>; Department of Oncology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Persson+GF%22">Persson GF</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bastholt+L%22">Bastholt L</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Poehl+M%22">Poehl M</searchLink>; Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ellebaek+E%22">Ellebaek E</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Donia+M%22">Donia M</searchLink>; Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address: marco.donia@regionh.dk.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jun 05; Vol. 243, pp. 116872. <i>Date of Electronic Publication: </i>2026 Jun 05.
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